| Research at Medicine |
| Prof Patrick McNeil |
 | Phone: 02 9828 4088 |  |
| Email: |
| Qualifications: BMedSc MB BS Tas, PhD UNSW, Grad Dip HEd, FRACP |
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| School/Unit: |
| South Western Sydney Clinical School
Department of Medicine |
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| Broad Research Areas: | |
| Arthritis / Rheumatology
Allergy
Inflammation
Immunology
Medical Education | |
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| Specific Research Keywords: | |
| Rheumatoid Arthritis
Autoimmune Disease
Atherogenesis and Inflammation
Asthma
Curriculum Development | |
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| Research Interests: | |
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Patrick McNeil heads a research group exploring mast cell biology and novel inflammatory pathways in rheumatoid arthritis and autoimmune connective tissue diseases, especially focusing on molecular mechanisms of inflammation. He has a long term focus on mast cell proteinases including characterisation of novel human tryptase genes, and the role of mast cell proteinases in rheumatoid arthritis. More recently he has research programs investigating expression of LLIR's in rheumatoid arthritis, and cardiovascular disease in rheumatoid arthritis. |
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| Teaching Interests: | |
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Broad interest in development of medical education programs especially in the areas of student-centred learning, innovations in teaching, learning and assessment, and recognition of quality teaching. Course and program evaluation and improvement. |
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| Society Memberships & Professional Activities: | |
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Australian Rheumatology Association
Australian Society for Medical Research
American Association of Immunology
Australian and New Zealand Association of Medical Educators |
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| Funding Sources: | |
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NH&MRC Project Grants
Arthritis Australia
ARC Linkage Grant
Clinical trials |
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| Key works/Publications: | |
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McNeil HP, Adachi R, Stevens RL. Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense. J.Biol.Chem. 2007;282:20785-20789.
McNeil HP, Hughes CS, Toohey SM, Dowton SB. An innovative outcomes-based medical education program built on adult learning principles. Medical Teacher 2006;28:527-534.
Cai, H, Song C, Endoh I, Goyette J, Jessup W, Freedman SB, McNeil HP, Geczy CL. Serum amyloid A induces monocyte tissue factor. J Immunol. 2007;178:1852-1860.
Huynh O, Hampartzoumian T, Arm J, Hunt JE, Borges L, Ahern M, Smith M, Geczy C, McNeil HP, Tedla N. Down regulation of leukocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying antirheumatic drugs. Rheumatology 2007;46:742-751.
Watson EGS, Moloney PJ, Hughes CS, Mobbs SL, Toohey SM, Leeper JB, McNeil HP. Development of eMedTM - a Comprehensive and Modular Curriculum Management System. Academic Medicine 2007;82:351-360.
Di Girolamo N, Indoh I, Jackson N, Wakefield D, McNeil HP, Yan W, Geczy C, Arm JP, Tedla N. Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration. J Immunol 2006;177:2638-2650.
Song C, Nakagomi A, Chandar S, Cai H, Lim IGS, McNeil HP, Freedman B, Geczy CL. C-reactive protein contributes to the hypercoagulable state in coronary artery disease. J Thromb Haemost 2006;4:98-106
Jackson NE, Wang HW, Tedla N, McNeil HP, Geczy CL, Collins A, Grimm MC, Hampartzoumian T, Hunt JE. IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor. Eur J Immunol. 2005:35;2376-2385
Wang H-W, Tedla N, Hunt JE, Wakefield D, McNeil HP. Mast cell accumulation and cytokine expression in the tight skin mouse model of scleroderma. Exp. Dermatol. 2005;14:295-302
Cai H, Song C, Lim IGS, Krilis SA, Geczy CL, McNeil HP. Importance of C-reactive protein in regulating monocyte tissue factor in patients with inflammatory rheumatic diseases. J.Rheumatol. 2005;32:1224-31
Katrib A, Smith MD, Ahern MJ, Slavotinek J, Stafford L, Cuello C, Bertouch JV, McNeil HP, Youssef PP. Reduced chemokine and matrix metalloproteinase expression in rheumatoid arthritis patients achieving remission. J.Rheumatol. 2003;30:10-21
Katrib A, McNeil HP, Youssef PP. What can we learn from the synovium in early rheumatoid arthritis? Inflammation Research 2002;51:170-175
Wang H-W, McNeil HP, Husain A, Liu K, Tedla N, Thomas PS, Raftery M, King GC, Cai ZY, Hunt JE. Delta tryptase is expressed in multiple human tissues and a recombinant form has proteolytic activity. J.Immunol. 2002;169:5145-5152
Tedla N, Gibson K, McNeil HP, Cosman D, Borges L, Arm JP. The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Am.J.Path. 2002;160:425-431
Gibson KA, Kumar R, Tedla N, Gotis-Graham I, McNeil HP. Expression of the aEb7 integrin by mast cells in rheumatoid synovium. J.Rheumatol. 2000;27: 2754-2760
Visvanathan S. McNeil HP. Cellular immunity to beta2-glycoprotein-1 in patients with the antiphospholipid syndrome. J.Immunol. 1999;162:6919-6925
Wang H, Tedla N, Lloyd A, Wakefield D, McNeil HP. Mast cell activation and migration to lymph nodes during induction of an immune response in mice. J.Clin.Invest. 1998.102:1617-1626
Tedla N, Wang H, McNeil HP, DiGiralamo N, Hampartzoumian T, Wakefield D, Lloyd A. Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines, MIP-1alpha and MIP-1beta. J.Immunol. 1998;161:5663-5672
Gotis-Graham I, McNeil HP. Mast cell responses in rheumatoid synovium. association of the MCTC subset with matrix turnover and clinical progression. Arthritis Rheum. 1997.40:479-489.
Gotis-Graham I, Hogg PJ, McNeil HP. Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium. Arthritis Rheum. 1997. 40:1780-1787.
McNeil HP. Aetiological pathways in osteoarthritis and inflammatory arthritis: rheumatoid arthritis. APLAR J. Rheumatol. 1998.2:139-142
Gotis-Graham I, Smith M, Parker A, McNeil HP. Synovial mast cell responses during clinical improvement in early rheumatoid arthritis. Annals Rheum. Dis. 1998.57:664-671
McNeil H.P., Austen K.F. Biology of the mast cell., in 'Samter's' Immunological Diseases. 5th Edition. Edit. Frank M.M, Austen K.F., Claman H.N., Unanue E.R. Little Brown & Co. Boston. 1995. Chap 13. P. 185-204
Sali A., Matsumoto R., McNeil H.P., Karplus M., Stevens R.L. Three-dimensional structures of four mouse mast cell chymases: identification of proteoglycan-binding regions and protease-specific antigenic epitopes. J.Biol.Chem. 1993.268:9023-9034
Gurish M.F., Nadeau J.H., Johnson K.R., McNeil H.P., Austen K.F., Stevens R.L. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. J.Biol.Chem. 1993.268:11372-11379
Stevens R.L., Friend D.S., McNeil H.P., Schiller V., Ghildyal N., Austen K.F. Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases. Proc.Natl.Acad.Sci.USA. 1994.91:128-132
Ghildyal N, Friend DS, Freelund R, Austen KF, McNeil HP, Schiller V, Stevens RL. Lack of expression of the tryptase, mMCP-7, in immature in vitro-derived mast cells and mature ear mast cells of the C57BL/6J mouse. J.Immunol. 1994.153:2624-2630
McNeil H.P., Reynolds D.S., Schiller V., Ghildyal N., Gurley D.S., Austen K.F., Stevens R.L. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7. Proc.Natl.Acad.Sci.U.S.A. 1992.89:11174-11178
Gurish M.F., Ghildyal N., McNeil H.P., Austen K.F., Gillis S., Stevens R.L. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin-3 and c-kit ligand. J.Exp.Med. 1992.175:1003-1012
Ghildyal N., McNeil H.P., Gurish M.F., Austen K.F., Stevens R.L. Transcriptional regulation of the mucosal mast cell specific protease, MMCP-2 by interleukin-10 and interleukin-3. J.Biol.Chem. 1992.267:8473-8477
Ghildyal N., McNeil H.P., Stechschulte S., Austen K.F., Silberstein D., Gurish M.F., Somerville L.L., Stevens R.L. IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice. J.Immunol. 1992.149:2123-2129
McNeil H.P., Frenkel D.J., Austen K.F., Friend D.S., Stevens R.L. Translation and granule localization of mouse mast cell protease-5. Immunodetection using specific antipeptide Ig. J.Immunol. 1992.149:2466-2472
McNeil H.P., Austen K.F., Somerville L.L., Gurish M.F., Stevens R.L. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. J.Biol.Chem. 1991.266:20316-20322
McNeil H.P., Hunt J.E., Krilis S.A. Antiphospholipid antibodies - new insights into their specificity and clinical importance. Scand.J.Immunology 1992.36:647-652
McNeil H.P., Simpson R.J., Chesterman C.N., Krilis S.A. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid- binding inhibitor of coagulation: beta2glycoprotein I (apolipoprotein H). Proc.Natl.Acad.Sci. U.S.A. 1990.87:4120-4124
McNeil H.P., Chesterman C.N., Krilis S.A. Immunology and clinical importance of antiphospholipid antibodies. Adv.Immunol. 1991.49:193-280 |
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