| Research at Medicine |
| Professor Philip Hogg |
 | Phone: Please contact School/Unit |  |
| Email: Please contact School/Unit |
| Qualifications: BSc, PhD Qld |
| |
| School/Unit: |
| UNSW Cancer Research Centre
|
| |
| Broad Research Areas: | |
| Biochemistry
HIV - AIDS | |
| | |
| Specific Research Keywords: | |
| Allosteric Disulphides
Protein Regulation
Cancer Drug Development and Pharmacology | |
| | |
| Research Interests: | |
|
Disulphide bonds are covalent links between pairs of cysteine amino acids. All life forms make this bond. Human cells, for instance, make about 3,000 different proteins that contain disulphide bonds. These bonds have been generally considered to be either structural or catalytic. Structural bonds stabilise a protein while catalytic bonds mediate thiol-disulphide interchange reactions in substrate proteins. There is emerging evidence for a third type of disulphide bond which can control protein function by triggering a conformational change when it breaks and/or forms. We have called these bonds ‘allosteric disulphides’. We have predicted that about one in fifteen of all structurally determined disulphides is a potential allosteric bond, implying a significant role for these bonds in controlling protein function. Viral, bacterial and human proteins have been shown to be controlled by allosteric disulphides. Our research focus is to characterise control of important proteins by allosteric disulphides, be able to predict allosteric disulphides in proteins, and to exploit allosteric disulphides for drug development. |
| | |
| Teaching Interests: | |
|
My teaching interests include fundamental protein chemistry and cell biology. My expertise is in vascular biology. |
| | |
| Society Memberships & Professional Activities: | |
|
Awards and Honours
W.R. Pitney Award, University of New South Wales (1992)
Tow Prize, Coast Medical Association, Sydney (1992)
R. Douglas Wright Fellowship, National Health and Medical Research Council of Australia (1993)
The Cecil Orlando Adcock Research Award, National Heart Foundation of Australia (1993)
The Walter A. Stimson Research Award, National Heart Foundation of Australia (1995)
Senior Research Fellowship, National Health and Medical Research Council of Australia (1996)
The Speywood Medal, Australian Society for Thrombosis and Haemostasis (1996)
The Ian Crawford Research Award, National Heart Foundation of Australia (1997)
The Nick Balagiannis Research Award, National Heart Foundation of Australia (1999)
Principal Research Fellowship, National Health and Medical Research Council of Australia (2000)
Commonwealth Health Minister's Award for Excellence in Health and Medical Research (2001)
GlaxoSmithKline Australia Award for Research Excellence (formally Wellcome Medal) (2001)
The GE Healthcare Bio-Sciences Award, Australian Society for Biochemistry and Molecular Biology (2006) |
| | |
| Funding Sources: | |
|
My research is supported by Program Grants from the National Health and Medical Research Council and the NSW Cancer Council, and Project Grants from the National Health and Medical Research Council and the National Heart Foundation. I am also supported by a Capital Works Grant from the Australian Cancer Research Foundation and an Infrastructure Grant from the NSW Health Department. |
| | |
|
|
|
|
|
|
| Key works/Publications: | |
|
Lay, A.J., Jiang, X.-M., Kisker, O., Flynn, E., Underwood, A., Condron, R. and Hogg, P.J. (2000) Phosphoglycerate kinase acts in tumor angiogenesis as a disulphide reductase. Nature 408, 869-873.
Xie, L., Chesterman, C.N. and Hogg, P.J. (2001) Control of von Willebrand factor multimer size by thrombospondin-1. J Exp Med 193, 1341-1349.
Matthias, L.J., Yam, P.T.W., Jiang, X.-M., Vandegraaff, N., Li, P., Poumbourios, P., Donoghue, N., and Hogg, P.J. (2002) Disulphide exchange in domain 2 of CD4 is required for entry of the Human Immunodeficiency Virus Type 1. Nature Immunol 3, 727-732.
Hogg, P.J. (2003) Disulphide-bonds as switches for protein function. Trends Biochem. Sci. 28, 210-214.
Don, A.S., Kisker, O., Dilda, P., Donoghue, N., Zhao, X., Decollogne, S., Creighton, B., Flynn, E., Folkman, J. and Hogg, P.J. (2003) A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell 3, 497-509.
Dilda, P.J., Don, A.S., Tanabe, K.M., Higgins, V.J., Allen, J.D., Dawes, I.W. and Hogg, P.J. (2005) Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. J Natl Cancer Inst 97, 1539-1547
Schmidt, B., Ho, L. and Hogg, P.J. (2006) Allosteric disulphide bonds. Biochemistry, in press
|
| | |
|
|
| | |
Need to update your profile? Click here to login with your Staff ID, prefixed by a lower case "s" or "z" (eg s1234567 or z1234567), and UniPass to update your profile. If you have any problems please send an email to .
|
|