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| Dr Romain Barres
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Type 2 diabetes (T2DM) remains a complex and multifaceted disease, the exact causes of which have yet to be resolved. While genetic predisposition can contribute to the development of T2DM, diet and physical activity can also have a positive impact on insulin sensitivity. Epigenetic modifications provide a mechanism by which external environmental factors such as exercise and diet can modify genetic predisposition for health and disease. My research activity is focused on the mechanisms underlying metabolic disorders with particular attention on human skeletal muscle. We identified that changes in the metabolic environment could lead to a dynamic epigenetic modulation of genes that have been implicated in the control of insulin sensitivity and the development of T2DM and related metabolic disorders.
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| Associate Professor David Champion
School of Women's and Children's HealthStatement of Interests:
In the field of paediatric pain, the program directed covers measurement and assessment, infant responses to pain, provision of information, child coping strategies, school functioning, childhood determinants of later life recurrent and chronic pain, quantitative sensory testing, growing pains, genetic [twin] research, genetic and environmental determinants of adverse pain experiences.
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| Professor Daniel Chan
South Western Sydney Clinical SchoolStatement of Interests:
Daniel KY Chan is a senior staff specialist and director of Aged Care and Rehabilitation at Bankstown-Lidcombe Hospital. He is also a conjoint Professor of Geriatrics at the University of New South Wales and an adjunct Professor at the University of Western Sydney. He has qualifications in clinical practice (FRACP, FHKCP), research (MD) and health service management (MHA, AFCHSE). He has been involved with many molecular biology, epidemiologyical, Parkinson's disease, stroke and health service related research. He has had 90 + publications in journals, about two-fifth of these as first author. Many are internationally reputable journals, some highly prestigious. Some of the best journals include New England Journal of Medicine (Impact Factor (IF 44.02, first author) , the top journals in neurology: “Neurology” (IF 5.973, first author), “Archives of Neurology” (IF: 4.835, three papers, first author once and second author once); “Annals of Neurology” (IF: 8.097, co-author), “Journal of Neurology Neurosurgery and Psychiatry” (IF: 3.11, first author) as well as top journals in Geriatrics: “Journal of the American Geriatric Society” (IF: 3.361, most senior author), “Journals of Gerontology” (IF 4.122, first author) and “Age & Ageing” (IF: 1.646, three papers, once first author and twice second author). He is also actively involved in the research area of stroke with publications in reputable journals: including JAGS (IF 3.361), Acta Neurologica Scandinavica (IF 1.712), Neuroepidemiology (IF 1.758) and Medical Journal of Australia (IF 2.0) (Publication list no 6,9,10,15,30,35). He has published a position statement - “Dysphagia and aspiration in older people” on the website on behalf of the Australian Society for Geriatrics Medicine (Publication list no 18). He has been successful in securing in excess of $2million from various competitive grants in recent years. Sources of grants include: NHMRC (ID 510275, CIA; ID 358372, CIF), Hong Kong Research Council; New South Wales Health Department; Pathway Home for elderly(Commonwealth); Australian Council for Safety and Quality in Health Care (Commonwealth); Royal Australasian College of Physicians (mostly as first applicant.
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| Dr David Chang
South Western Sydney Clinical School | |
| Dr Raymond A Clarke
St George Clinical School - Department of MedicineStatement of Interests:
Cancer biomarkers can reflect the causal pathway linking disease to outcome. Prostate cancer antigen 3 (PCA3) is a highly specific biomarker upregulated in prostate cancer (PCa). In order to understand the role of PCA3 we investigated the organization and evolution of the PCA3 gene locus. We identified 4 new transcription start sites in an extended form of PCA3, 2 new exons, exons 2a and 2b, and evidence for 4 new polyadenylation sites. PCR amplification based on the new exon sequences provided excellent discrimination between PCA3 expression in PCa, PCa metastases and BPH. At the genomic level PCA3 is embedded in the opposite (anti-sense) orientation in a second gene, BMCC1 / PRUNE2, that contains a BNIP2 and Cdc42GAP homology (BCH) domain capable of interacting with RhoA and RhoC, determinants of cellular transformation and metastasis, respectively. Comparative genomic analysis demonstrates that PCA3 emerged in mammals and recently evolved in primates and the upstream region of the BMCC1 isoform 1 (BMCC1-1) that flanks the PCA3 gene has only recently evolved. We also demonstrated that BMCC1-1 – like PCA3 – is upregulated in PCa tissue and metastases and in PCa cell lines. We are now investigating the relationship between BMCC1 upregulation and prostate cancer progression.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Associate Professor Sally Dunwoodie[</b><br>    <i>St Vincent](/icons/expand.gif) Associate Professor Sally Dunwoodie
St Vincent's Clinical SchoolStatement of Interests:
The genetic analysis of development in the mouse has direct relevance to the molecular basis of congenital abnormalities and other pathological conditions, such as neoplasia, in humans. Consequently current research in the laboratory focuses on: Identifying and characterising genes relevant to mammalian embryonic development; Notch signaling and the role of Delta-like3 (Dll3) in vertebral column formation; and the role of HIF1a (hypoxia inducible factor 1) and Cited2 in formation and function of the heart and placenta.
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| Professor Valsamma Eapen
School of PsychiatryStatement of Interests:
In the area of Child and Adolescent Psychiatry, special areas of focus include epidemiology, genetic underpinnings, neurocognitive processes and clinical presentation of neurodevelopmental disorders such as Tourette Syndrome, Autism, Obsessive Compulsive Disorder, and Attention Deficit Hyperactivity Disorder. Other areas of interest include anxiety in young children and metabolic syndrome in adolescents with mental illness.
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| Professor John French
South Western Sydney Clinical School - Department of MedicineStatement of Interests:
John’s major clinical research focus has been in the acute coronary syndromes, particularly on the assessment of myocardial reperfusion assessed by infarct-related artery blood flow, ST recovery, left ventricular function, and late clinical outcomes in patients with ST elevation myocardial infarction. He has been an active researcher having been an investigator and co-investigator in numerous randomised controlled trials and clinical trials and was on the writing committee of the HERO-2 trial. John was on the steering committee for the SHOCK, OAT and HERO-2 trials and he was the chair of the myocardial infarction adjudication committee and ECG sub-study for HERO-2. As part of a continuing interest in molecular medicine John has established the cardiac genetics clinics with the genetics department, and is a member of TRAGADY. John has co-authored >120 peer-reviewed publications and six book chapters. He has supervised a number of MD and MHSc postgraduate students and has been invited speaker at recent American College and American Heart Association meetings.
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| Dr Luke Hesson
Prince of Wales Clinical SchoolStatement of Interests:
Research within the Molecular and Cellular Oncology Laboratory aims to investigate the genetic and epigenetic basis of colon cancer.
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| Dr Megan Hitchins
Prince of Wales Clinical SchoolStatement of Interests:
Research focus is the role of genetic and epigenetic changes in disease development including both congenital disorders and cancer, and the inheritance patterns associated with these molecular abnormalities. This has included research into the aetiological role of genomic imprinting during fetal development, and more recently, germline epimutations in hereditary cancers. The patterns of somatic epigenetic changes in the development of sporadic cancer, and the underlying mechanisms are also of interest.
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| Dr Yue Huang
School of Medical SciencesStatement of Interests:
Current research is focus on Parkinson’s disease and related disorders, with a particular interest in molecular biomarkers for clinical diagnosis and prognosis of Parkinson’s disease and early detection of dementia syndrome; cross cultural comparison on epidemiological, clinical and pathological features of the disorders; as well as human brain tissue analysis on the formation and maturation of disease characteristic pathological lesions (Lewy bodies of Parkinson’s disease, glial cytoplasmic inclusions of multiple system atrophy and coil bodies of progressive supranuclear palsy).
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| Dr John Hunt
School of Medical Sciences - Department of PathologyStatement of Interests:
My research interests focus on mast cell biology and the discovery and molecular characterisation of novel mast cell proteases. We have recently discovered a number of novel human mast cell tryptases, and we are currently determining their substrate specificity. Another aspect of our work involves the characterisation of factors that control the biology of mast cells. We have demonstrated that IL-15 is one of the most potent mast cell attractants yet reported, and aslo acts to upregulate the expression of ubiquitin-protein ligase 3B, matrix metalloproteinase 9 (MMP9) and apolipoprotein CI (ApoC1) by mast cells.
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| Dr Edwin Kirk
School of Women's and Children's HealthStatement of Interests:
Congenital heart disease (CHD) is largely genetic in origin. Mapping and candidate gene studies in collaboration with the Victor Chang Cardiac Research Institute and the Faculty of Veterinary Science at Sydney University have revealed a role for TBX20 in rare familial forms of CHD and identified 13 QTL influencing aspects of atrial septal morphology. The psychological impact of prenatal diagnosis of CHD is another area of interest. Other research interests include inherited metabolic disease, chromosomal abnormalities and congenital hypothyroidism, with a collaboration with the Hong Kong Genetic Neonatal Screening Program commencing in 2008.
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| Dr Maija Kohonen-Corish
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Our area of expertise is colorectal and lung cancer genetics/epigenetics and we currently have both translational and experimental research projects. We examine the gene profiles of resected tumour tissues and correlate them with patient clinical outcomes. The challenge is to work out which key gene alterations and biomarkers are the most useful for determining prognosis and treatment outcomes, in order to improve the clinical management of patients. We have also identified new genes that are inactivated through epigenetic mechanisms in cancer, and want to understand the biological significance of these gene defects using cell line and mouse models.
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| Dr Nicola Man
School of Public Health and Community MedicineStatement of Interests:
Research experience in the area of population and quantitative genetics, genetics of disease resistance, statistical analysis of genetic data and simulation studies of populations undergoing genetic selection. Current research interest extend to epidemiology with respect to stochastic modelling of infectious diseases, host-pathogen evolution and statistical analysis of biological and epidemiological data.
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| Ms Karen Mather
School of PsychiatryStatement of Interests:
The main research focus is to gain a better understanding of the genetic and environmental factors involved in ageing and age-related disease. The genetic factors that may be involved include variation at the nucleotide level, epigenetic variation, epistasis and gene-environmental interactions. Current research is being undertaken using large population cohorts of older Australians and examining the genetic variation and environmental factors associated with ageing phenotypes.
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| Associate Professor Bettina Meiser
Prince of Wales Clinical SchoolStatement of Interests:
An ongoing research program that incorporates both qualitative and quantitative research methodologies focuses on the psychological impact of genetic testing and counselling for adult-onset disorders, in particular cancer susceptibility; psychological adjustment of those at risk for adult-onset disorders; the design and evaluation of interventions in the genetic counselling setting, in particular decision aids as an innovative means of patient education; and the impact of prophylactic surgery in individuals at high risk for cancer. Another area of research is cultural aspects of cancer genetics.
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| Scientia Professor Philip Mitchell
School of PsychiatryStatement of Interests:
"High risk" longitudinal study of young people at genetic risk for bipolar disorder. Molecular genetics of bipolar disorder. Treatment of bipolar disorder - psychological and pharmacological. Phenomenology of bipolar depression. Transcranial magnetic stimulation and direct current stimulation as treatments for depression and other psychiatric disorders.
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| Mr Allan Motyer
Prince of Wales Clinical School | |
| Professor Dedee Murrell
St George Clinical School - Department of MedicineStatement of Interests:
Clinical dermatology Research • quality of life studies in blistering diseases; epidemiology of Epidermolysis bullosa and autoimmune blistering diseases in Australia; Basic/Translational research: genotype-phenotype correlations in epidermolysis bullosa • gene and cell therapy for dystrophic epidermolysis bullosa • autoantigen mapping in pemphigus and pemphigoid • squamous cell carcinoma and angiogenesis factors Dermatopharmacology Research • photodynamic therapy for non-melanoma skin cancer • trials of new therapies for psoriasis • evidence based therapies and measurement tools for blistering diseases ; Supervision of ILP students since the program started - the first student, John Frew, won the prize for the best project at the Annual Symposium at St George Hospital in 2007 (Development of a quality of life scale, the QOLEB, for EB); Yong Kho won the same prize in 2008 (Establishment of the Australasian EB Registry); all ILP students have had high distinctions and oral and poster presentations at local, national and some at International conferences, and published papers.
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| Professor Tuan Van Nguyen
School of Public Health and Community MedicineStatement of Interests:
I have two main interests in osteoporosis research: epidemiology of osteoporotic fractures and genetics of osteoporosis. In terms of epidemiology, my group’s research interests are mainly in the study of determinants of fracture and the development of prognostic models for predicting fracture risk in an individual patient. A second focus of my group’s research is concerned with the genetics of osteoporosis. We are specifically interested in finding novel genes that are involved in the regulation of bone phenotypes, including bone mineral density and fracture. Current research projects: * Development of prognostic models for the assessment of fracture risk * Development of new phenotype for osteoporosis * Determinants of bone loss and the concept of risk individualization * Hormonal determinants of diabetes, cancer and osteoporosis * Bayesian models for epidemiologic data * Genomewide association study of osteoporosis genes * Genomewide linkage analysis of bone phenotypes I currently have a number of projects that are suitable for masters and PhD candidates. I am looking for candidates with strong background in clinical epidemiology, genetics, and biostatistics with solid knowledge in Bayesian modeling. Interested candidates can contact me via email at tuan.nguyen@unsw.edu.au or t.nguyen@garvan.org.au for more detailed description of these projects.
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| Dr Philippa O'Brien
St Vincent's Clinical SchoolStatement of Interests:
The molecular basis of epithelial ovarian cancer is poorly understood. Our laboratory is using contemporary microarray-based genomic tools in to identify genes involved in the development and progression of ovarian cancer, with the aim of identifying new clinical biomarkers. Our current primary focus is to identify epigenetically regulated genes in ovarian cancer, including epigenetically silenced tumour suppressor genes, and epigenetic changes that occur in the very early stages of ovarian cancer. We are also investigating the potential of epigenetic alterations as the basis of new detection tests for early stage curable disease, and as novel therapeutic targets.
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| Dr Stephen Palmer
School of Medical SciencesStatement of Interests:
1.Understanding the role of the gene Gtf2ird1 in brain development and human behaviour and its contribution towards the characteristic features of Williams-Beuren syndrome. 2. Understanding the gene regulatory networks involved in the control of muscle fibre type in order to develop strategies to combat the effects of disease and ageing.
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| Associate Professor Thomas Preiss
St Vincent's Clinical School - Victor Chang Cardiac Research InstituteStatement of Interests:
Click to view research interests and key publications - http://www.victorchang.edu.au/research/ProfThomasPreiss.cfm?cid=79
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| Dr Arun Sondur Jayappa
South Western Sydney Clinical School | |
| Dr Duncan Sparrow
St Vincent's Clinical SchoolStatement of Interests:
The genetic analysis of development in the mouse has direct relevance to the molecular basis of congenital abnormalities and other pathological conditions, such as neoplasia, in humans. Consequently current research in our laboratory focuses on: Identifying and characterising genes relevant to mammalian embryonic development; Notch signaling and its role in somite and consequently vertebral column formation; and the roles of Cited1 and Cited2 in formation and function of the heart and placenta.
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| Associate Professor Julian Trollor
School of Psychiatry - Intellectual Disability Mental HealthStatement of Interests:
Research projects are available to suit a variety of students at the ILP, Honours, Masters and PhD level. There are 3 broad streams to my current research: 1. Brain Ageing: determinants and correlates of brain ageing with a focus on brain imaging, metabolic, cardiovascular and inflammatory factors, nutrition, and gene-environment inteactions. Study data is derived from two large ageing gohorts, the Sydney Memory and Ageing Study and the Older australian Twins Study. 2. Developmental Disability Neuropsychiatry: a number of focus areas including ageing and dementia in intellecutally disabled adults, intellecual disability mental health within the criminal justice system, human rights issues in health care of intellecually disabled adults. 3. Other Neuropsychaitric Disorders: I have an established interest in a variety of neuropsychaitric conditions including the neuropsychiatry of epilepsy, adult ADHD, novel treatments for depression (including VNS)and drug induced movement disorders including NMS.
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| Mr Guy Tsafnat
Australian Institute of Health Innovation - Centre for Health InformaticsStatement of Interests:
I am primarily interested in larger-than-gene structures in DNA, they recognition, annotation and discovery. We use machine learning, computational grammars and inference methods to computationally discover structures and genes. I am also interested in multi-scale and multi-method models (aka multi-models) to support clinical and bioscience decision making.
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| Dr Ute Vollmer-Conna
School of Psychiatry - Department of Human BehaviourStatement of Interests:
The field of Psychoneuroimmunology, with a particular focus of cytokine-induced changes in behaviour, emotion, motivation and cognition. Additional interests include the effect of genetic polymorphisms on the severity and duration of illness following acute infection. Cross-disciplinary research involves colleagues from Pathology/Immunology, Virology, Psychiatry, Psychology and General Practice.
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| Professor Robyn Ward
Prince of Wales Clinical SchoolStatement of Interests:
In the field of hereditary cancer, the impact of germline epimutations as a cause of cancer is a main field of study. This work represents a substantive change in our understanding of colorectal cancer predisposition, and is of clinical relevance. In the clinical field research studies involve interventional and observational studies of targeted therapies for cancer. In health policy, the research activities revolve around developing cost effective models for the use of cancer medicines in our community.
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| Professor Susan Wilson
Prince of Wales Clinical SchoolStatement of Interests:
Development and application of novel statistical approaches to analysis of complex genomic data
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