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| Professor Minoti Apte
South Western Sydney Clinical SchoolStatement of Interests:
Pancreatitis is a major complication of alcohol abuse. The pathogenesis of alcohol-induced pancreatic injury is a major interest. Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and pancreatic cancer. Mechanisms responsible for pancreatic fibrogenesis, in particular the role of pancreatic stellate cells in the fibrosis of chronic pancreatitis as well as pancreatic cancer is being studied. National and international collaborations have been set up to study the role of pancreatic stellate cells in the local and distant spread of pancreatic cancer.
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| Dr Tobias Arkenau
Prince of Wales Clinical SchoolStatement of Interests:
In the field of cancer medicine the development of new anti-cancer agents is of special interest, with a special focus on the treatment of gastro-intestinal cancers. Additionally, clinical trial design and biomarker development.
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| Associate Professor Paul Bertrand
School of Medical SciencesStatement of Interests:
The goal of my research is to understand the neuronal basis of disease with an emphasis on the compounds ATP & serotonin (5‑HT) and the roles they play in neurotransmission & sensory transduction. My laboratory focuses on the neurophysiology of the gastrointestinal tract using electrophysiological and electrochemical methods.
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| Dr Rebecca Bertrand
School of Medical SciencesStatement of Interests:
The gastrointestinal tract turns out to be quite a complicated organ. You might think it's just absorb this and poop that, but how does that really happen? A lot of it is controlled by a massive network of neurons located within the gut (called the enteric nervous system) - that's right, the brain isn't the only place where a whole bunch of neurons live. We investigate how this network of neurons manages to control the workings of the intestine without any help from the brain. We record from individual neurons (intracellular electrophysiology) to see how they communicate with their neighbours and how the neighbours talk to them (synaptic transmission). We also look at it from the whole organ level.
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| Professor Elizabeth Burcher
School of Medical Sciences - Department of PharmacologyStatement of Interests:
a) neurochemicals in human intestine: alterations in disease. b) neurochemicals in the human bladder: relevance to urinary incontinence. c) urothelium of the pig bladder as a model for human bladder studies.
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| Dr David Chang
South Western Sydney Clinical School | |
| Dr Rajkumar Cheluvappa
St George Clinical SchoolStatement of Interests:
Inflammatory Bowel Disease
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| Professor Ian Cook
St George Clinical School - Department of MedicineStatement of Interests:
Physiology, pathophysiology and management of swallowing and its disorders. Evaluation of novel techniques to assess the biomechanics of the pharyngeal swallow (combined manometry &radiography, high resolution manometry, intraluminal impedance, scintigraphy). Novel approaches to evaluation and treatment of pharyngeal dysphagia. Study of oesophageal afferent nerve function and reflexes and how these impact reflux disease and its complications including regurgitation and respiratory complications. Pathophysiology of oesophago-pharyngeal regurgitation and reflux laryngitis. Pathophysiology of functional heartburn. Application of novel techniques in the evaluation of colonic motor and sensory function (pancolonic manometry, scintigraphy, intraluminal impedance). Relationships among colonic pressures, transit and defaecation. Pathophysiology of constipation syndromes. Novel therapeutic approach to treatment of severe constipation (eg sacral nerve stimulation).
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| Associate Professor Andrew Day
School of Women's and Children's HealthStatement of Interests:
Host pathogen interactions in the gut and gastrointestinal inflammatory responses with regards to Paediatric Inflammatory Bowel Disease and Helicobacter pylori infection. Roles of S100 proteins in gut inflammation. Roles of other inflammatory mediators in the gut. Host responses to infection with the bacterium Helicobacter pylori and the contributions played by gastrointestinal epithelial cell cytokines during infection Roles of probiotics and nutriceuticals in gastrointestinal diseases
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| Dr Philip Dinning
St George Clinical School - Department of MedicineStatement of Interests:
Our research aims to clarify the contractile patterns of the human colon which underlie the very common and distressing condition of constipation. We are currently relating symptoms of constipation from a large number of sufferers with actual measurements of contractions and flow of content along the colon in these patients. The aim of our projects is to identify abnormal motor patterns responsible for constipation as well as determining a possible inductor of normal colonic motility so that future studies can target appropriate treatment at the responsible defect.
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| Professor Gregory Dore
National Centre in HIV Epidemiology & Clinical ResearchStatement of Interests:
Clinical epidemiology and clinical research in the areas of viral hepatitis and HIV/viral hepatitis co-infection are broad research focus areas. More specifically, natural history of hepatitis C infection and natural history and therapeutic research in HIV/viral hepatitis co-infection. Other specific areas of research interest include quality of life in hepatitis C, HIV-related hepatotoxicity, and modelling of the epidemiology of hepatitis C.
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| Professor Michael Grimm
St George Clinical School - Department of MedicineStatement of Interests:
A number of research projects in the Department of Gastroenterology, St George Clinical School, and the Inflammatory Diseases Research Unit, School of Medical Sciences. The research areas include the following : cross-regulation of chemokines and chemokine receptors; immunopathogenesis of inflammatory bowel disease; novel therapeutic strategies in inflammatory bowel disease; mucosal immunity and lymphocyte trafficking; regulatory T lymphocytes and other mechanisms controlling gastrointestinal immunity; the role of the appendix in gut immunity and IBD
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| Professor Nick Hawkins
School of Medical Sciences - Department of PathologyStatement of Interests:
In terms of colorectal (bowel) cancer, the work of the laboratory is focussed on understanding the molecular changes that drive the process of cancer development. There is an emphasis on the role of DNA methylation in the development of bowel cancer, and on the correlation between microscopic appearances of cancer, and the key genetic changes occuring in the tumour.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Dr Maija Kohonen-Corish[</b><br>    <i>St Vincent's Clinical](/icons/expand.gif) Dr Maija Kohonen-Corish
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Our area of expertise is colorectal and lung cancer genetics/epigenetics and we currently have both translational and experimental research projects. We examine the gene profiles of resected tumour tissues and correlate them with patient clinical outcomes. The challenge is to work out which key gene alterations and biomarkers are the most useful for determining prognosis and treatment outcomes, in order to improve the clinical management of patients. We have also identified new genes that are inactivated through epigenetic mechanisms in cancer, and want to understand the biological significance of these gene defects using cell line and mouse models.
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| Dr Daniel Avi Lemberg
School of Women's and Children's HealthStatement of Interests:
Non-Alcoholic liver disease (NAFLD) is a term to describe liver damage in obese patients. Currently while their is information as to the inflammatory cascade set-up in this entity; in a collaboration with colleagues at the University of British Columbia (UBC) we are investigating possible pathways that trigger this cascade. There continues to be great uncertainty as to the cause of The Inflammatory Bowel Diseases in children. In collaboration with collleagues at UNSW and UBC we aim to study demographic trends in children with IBD in particular Crohn's Disease and possible microbiological or environmental triggers for this illness.
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| Associate Professor Rupert Leong
South Western Sydney Clinical SchoolStatement of Interests:
Inflammatory bowel disease: - epidemiology - clinical drug trials - endoscopic mucosal imaging - genetics - proteomics in phenotyping and prognostication - qualitative research, quality of life. Endoscopy: - endoscopic ultrasound fine needle aspiration for biomarkers - confocal endomicroscopy Colorectal Cancer: - epidemiology, outcomes research - molecular biomarkers Collaborations: - Chinese University of Hong Kong - University of Western Australia - University of Sydney - Sydney South West Area Health Service: Bankstown Hospital, Concord Hospital
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| Dr Lu Liu
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Neurochemicals and receptors in regulation of gut function
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| Dr Reginald Lord
St Vincent's Clinical SchoolStatement of Interests:
The major focus of our work is on oesophageal diseases, especially oesophageal adenocarcinoma and its precursor Barrett’s oesophagus. Barrett’s oesophagus is the disease in which the normal squamous lining of the distal oesophagus is replaced by a metaplastic columnar lining containing goblet cells (intestinal metaplasia) in response to chronic severe gastro-oesophageal reflux. Worldwide, oesophageal cancer is the fifth commonest cause of cancer death in males and seventh in females. The risk of oesophageal cancer in males in Australia is 1 in 87 by age 85 years and the projected annual increase in new cases is 32%. Oesophageal cancer has a high case-fatality rate with population-based 5 year survival rates typically between 10% and 17%. In Australia there were 1,165 new cases and 1,176 deaths in 2005 and oesophageal cancer is the 10th most common cause of cancer death overall and 8th most common cause in males (Australian Institute of Health and Welfare (AIHW) & Australasian Association of Cancer Registries (AACR). Cancer in Australia: an overview, 2008. Cancer series no. 46. Cat. no. CAN 42. 2008. Canberra, AIHW). The incidence of EAC is increasing faster than any other cancer, with a more than 6-fold increase in the US in the past several decades. EAC incidence is increasing rapidly in Australia.
We investigate the genetic basis of this disease, especially changes in expression and DNA methylation in the Barrett’s multistage carcinogenesis model, prognostic factors for oesophageal cancer, and predictors of response to flouropyrimidine (eg 5-fluorouracil, 5-FU) and platinum drug (eg cisplatin) chemotherapy for patients with oesophageal cancer. Other interests are the immune response, especially involving dendritic cells, in Barrett’s oesophagus, adipokines and other factors involved in obesity, the relationship between obesity and cancer, and clinical studies of surgical outcomes and endoscopic Barrett’s ablation.
The laboratory is located in the St. Vincent’s Centre for Applied Medical Research on level 8 of the Lowy Packer Building, Liverpool Street, Darlinghurst 2010. Enquiries can be directed to Associate Professor Lord at rvlord@stvincents.com.au or (02) 8382-6671.
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| Associate Professor Neil Merrett
South Western Sydney Clinical School - Department of SurgeryStatement of Interests:
Major interest in in the area of linkage and application of laboratory research to clinical practice and clinical research in the areas of gastric and pancreatic tumours. This also encompasses the building of web based databases across multiple units for gastric and pancreatic tumours
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| Professor Allan Spigelman
St Vincent's Clinical School - Department of SurgeryStatement of Interests:
Hereditary cancer; Patient Safety and Clinical Quality; Cancer Genetics
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| Professor Robyn Ward
Prince of Wales Clinical SchoolStatement of Interests:
In the field of hereditary cancer, the impact of germline epimutations as a cause of cancer is a main field of study. This work represents a substantive change in our understanding of colorectal cancer predisposition, and is of clinical relevance. In the clinical field research studies involve interventional and observational studies of targeted therapies for cancer. In health policy, the research activities revolve around developing cost effective models for the use of cancer medicines in our community.
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