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| Dr Romain Barres
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Type 2 diabetes (T2DM) remains a complex and multifaceted disease, the exact causes of which have yet to be resolved. While genetic predisposition can contribute to the development of T2DM, diet and physical activity can also have a positive impact on insulin sensitivity. Epigenetic modifications provide a mechanism by which external environmental factors such as exercise and diet can modify genetic predisposition for health and disease. My research activity is focused on the mechanisms underlying metabolic disorders with particular attention on human skeletal muscle. We identified that changes in the metabolic environment could lead to a dynamic epigenetic modulation of genes that have been implicated in the control of insulin sensitivity and the development of T2DM and related metabolic disorders.
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| Dr Hui Chen
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The effects of maternal nutrition interventions on appetite, body weight, hormones (plasma leptin, insulin), lipids, and brain peptide expression invovled in appetite and glucose metabolism in offspring are of interest. A palatable high fat diet (32% fat) is being used to induce maternal obesity. This approach will be used to address the possibility of preventing childhood obesity by drugs and behaviour interventions. A second area of study deals with the effects of cigarette smoking on appetite, body weight, plasma leptin, and hypothalamic peptides expression to address wasting diseases.
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| Associate Professor Elizabeth Comino
Centre for Primary Health Care and EquityStatement of Interests:
My primary research interest is access to ‘best practice’ primary health care. I have substantial experience with analysis of large data collections and data linkage. I lead research that includes descriptive studies into access to care for people with diabetes, use of administrative data to describe access to and use of well baby clinics, and intervention research of management of chronic respiratory disease, and an NHMRC funded birth cohort study of Aboriginal infants in an urban community. This study is describing the health, development and health service use of Aboriginal children in an urban environment and is the first of its kind on the eastern seaboard of Australia.
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| Associate Professor Maria Craig
School of Women's and Children's HealthStatement of Interests:
My major research interest is childhood diabetes, including the association between enteroviruses and type 1 diabetes (in collaboration with the Virology Research Group at POWH, headed by Prof W Rawlinson) and the epidemiology of childhood diabetes (type 1 and type 2). I am also actively involved in research into diabetes complications (in collaboration with Assoc Prof Kim Donaghue at the Children's Hospital at Westmead).
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| Professor Ric Day
St Vincent's Clinical SchoolStatement of Interests:
Rheumatic disorders and Diabetes are prevalent chronic illnesses that demand high quality pharmacotherapy. We are researching powerful techniques for individualising pharmacotherapy using pharmacokinetic/pharmacodynamic models. Our aim is safe yet effective therapy. Allopurinol used in gout and metformin used in diabetes are currently being studied. Also we are investigating the mechanisms of paracetamol actions. We are examining genetic factors that predict serious adverse drug reactions and explain variation in response to medicines. The effects of electronic medication management in a teaching hospital on the rate of adverse events occurring is a new research interest.
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| Dr Mahnaz Fanaian
Centre for Primary Health Care and EquityStatement of Interests:
There is considerable evidence for the effectiveness of interventions to prevent cardiovascular disease at the population and individual levels. Given the contribution of cardiovascular disease to the burden of disease, the cost of inadequate prevention is high.. Large, population-based studies in China, Finland and USA have recently demonstrated the feasibility of preventing, or delaying, the onset of diabetes in overweight subjects with impaired glucose tolerance (IGT). The studies suggest that even moderate reduction in weight and only half an hour of walking each day reduced the incidence of diabetes by more than one half.
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| Dr Jeff Flack
South Western Sydney Clinical School - Department of MedicineStatement of Interests:
My main area of research interest is in Datasets and Quality Audit & Benchmarking in Diabetes utilising Computer Technologies.
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| Dr Jenny Gunton
St Vincent's Clinical SchoolStatement of Interests:
Diabetes develops when the beta-cells in the pancreas are no longer able to make enough insulin to control blood glucose levels. My research interest is to understand the mechanisms behind beta-cell failure in type 1 diabetes (childhood onset / IDDM), type 2 diabetes (adult-onset / NIDDM) and diabetes in pregnancy (Gestational Diabetes).
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| Professor Mark Harris
Centre for Primary Health Care and EquityStatement of Interests:
Major research interests include:- 1. Prevention and management chronic diseases especially diabetes cardiovascular disease, in primary care. 2. Health inequalities research including interventions to improve the health status of disadvantaged groups including the unemployed, refugees (asylum seekers) and Aboriginal people.
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| Dr Upali Jayasinghe
Centre for Primary Health Care and EquityStatement of Interests:
My research mainly focuses on application of multilevel modeling and other statistical methods, particularly in Health and medical research.
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| Dr Anthony Kee
School of Medical Sciences - Department of AnatomyStatement of Interests:
Interests are in the fields of muscle physiology and cell biology. Particularly interested in aspects of novel structural and cytoskeletal proteins and complexes and their involvement in normal muscle physiology and disease processes. Diseases of interest include muscular dystrophy and other congenital myopathies, diabetes and obesity. Have an interest in treatment of muscle diseases, including exercise.
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| Dr Lee Krahe
Rural Clinical School - Mid North Coast Division - Port Macquarie CampusStatement of Interests:
Vascular and cardiovascular diseases are major factors in morbidity and mortality in patients with Type 2 diabetes. Studies have shown that lifestyle intervention, including diet and exercise, may halt the progression from impaired glucose tolerance to overt type 2 diabetes. The challenge for clinicians is implementation of research results into clinical practice. Developing an exercise prescription -achievable for patients in the 'everyday'- is one such research avenue worthy of pursuit.
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| Dr Arun Krishnan
School of Medical SciencesStatement of Interests:
My major area of interest is in the area of clinical neurophysiology, particularly in the use of nerve excitability techniques as a means of investigating the pathophysiology of neuropathic processes. Measurements of excitability are cutting-edge techniques that provide information related to the activity of a variety of ion channels, energy-dependent pumps and ion exchange processes activated during impulse conduction. These are novel techniques which our group has applied to the study of mechanisms underlying the development of neuropathy and nerve injury. Specifically, we have applied these techniques to the study of metabolic and toxic neuropathies including those that occur secondary to diabetes, end-stage kidney disease (ESKD) and chemotherapy. Other studies have explored the responses of nerves to ischaemia, natural activity and altered electrolyte balance. Recently, excitability techniques have been applied to the assessment of cortical excitability using transcranial magnetic stimulation and we propose to apply these techniques to the study of neurodegenerative processes and central channelopathies.
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| Dr Cindy Lin
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Clinical application of nerve excitability testing Measuring multiple excitability properties of large human motor and sensory axons using threshold tracking techniques and software (QTRAC © Institute of Neurology), provide information about human axons that is different from, and complementary to, conventional nerve conduction studies. For example, excitability measures are much more sensitive to changes in resting membrane potential than measurements of conduction velocity. These methods are being applied to a range of conditions affecting human peripheral nerves, in order to help determine the pathophysiology of the neuropathy, or to improve diagnosis. Neuropathies currently under investigation include those associated with diabetes, uraemia and other metabolic disorders, and those associated with the chemotherapy in cancers.
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| Dr Sandy McColl
Rural Clinical School - Mid North Coast Division - Port Macquarie CampusStatement of Interests:
The use of exercise and lifestyle modication and its' effect on various pathologies ia a major interest. The transition of laboratory findings to implementation in day-to-day clinical practice is also an important consideration.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Professor Margaret J Morris[</b><br>    <i>School of Medical](/icons/expand.gif) Professor Margaret J Morris
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Obesity - Alterations to brain Neuropeptide Y (NPY) causes increase food intake. Our laboratory is exploring the brain mechanisms involved in appetite. Obesity is a world-wide problem. The brain regulates appetite throught the actions of a complex array of neurotransmitters that either increase or decrease feeding. Professor Morris and her team use animal models of obesity to explore the brain mechanisms involved in appetite, and the changes that occur in these systems during the development of obesity. Their work aims to improve our understanding of how the brain regulates feeding and to provide new insight into potential treatments for obesity and other feeding disorders. Diabetes - The effect of diabetes on how the brain senses hypoglycemia Epilesy - Collaboration with Royal Melbourne Hospital, examining the involvement of NPY on absence seizures. Further work examines the mechanisms by which some anti-epilepy drugs make seizures worse.
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| Dr Philip Peake
Prince of Wales Clinical SchoolStatement of Interests:
Adiponectin is an adipocyte specific hormone with insulin sensitising, anti-inflammatory and anti-atherogenic properties. Research concerns its behaviour in renal and other diseases, its physiochemical structure, and its interactions with other molecules, including those of the complement system.
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| Dr Tertia Purves-Tyson
Prince of Wales Medical Research InstituteStatement of Interests:
I am interested in the intracellular signalling mechanisms in autonomic pelvic ganglia and other peripheral ganglia (sensory dorsal root ganglia; sympathetic superior cervical ganglia) that are involved in neurodegeneration as a result of diabetes-induced nerve damage (diabetic neuropathy). An aim is to determine neuroprotective mechanisms in these neuron populations for potential neurotherapeutic intervention. I am also investigating estrogens and androgens as potential neurotherapeutic agents. Work is carried out both in vitro and in vivo.
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| Dr Carsten Schmitz-Peiffer
St Vincent's Clinical SchoolStatement of Interests:
The development of insulin resistance in skeletal muscle and liver is a key feature in the pathogenesis of type 2 diabetes. Insulin resistance is strongly associated with increased lipid availability, although the precise mechanisms involved remain to be elucidated. The Insulin Signalling Group at the Garvan Institute employs animal and cell culture models to study lipid metabolism and the inhibitory signalling pathways initiated by lipids which interfere with normal insulin action.
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| Dr David Simar
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
My research interests are mainly focused on the characterisation of metabolic dysfunctions in the immune system and skeletal muscles as well as the critical role played by inflammation in the development of those alterations in metabolic and immune conditions.
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| Ms Jane Taggart
Centre for Primary Health Care and EquityStatement of Interests:
Interested in research to improve the prevention and management of chronic disease patients in primary health care, particularly for diabetes and cardiovascular disease. Also interested in the organisation of primary health care to improve chronic illness care.
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| Dr Shane Thomas
Centre for Vascular ResearchStatement of Interests:
The Redox Cell Signalling Laboratory focuses on two major research areas:
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| Dr Charles Verge
School of Women's and Children's HealthStatement of Interests:
(1) Early diagnosis of insulin deficiency (and diabetes) in children and adolescents with cystic fibrosis (2) Studies on the duration of adrenal suppression following prednisone treatment, using the return of diurnal variation in salivary cortisol levels as the main outcome (3) Randomised controlled trials in the management of children/adolescents with type I diabetes (4) Monogenic diabetes
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| Dr Chris White
Prince of Wales Clinical School - Department of MedicineStatement of Interests:
The research focus in gestational diabetes is to identify physiologic mechnisms responsible for development of the syndrome and tools that can be used for its reliable diagnosis. Screening and diagnostic strategies need to be developed as well as prenatal and postnatal management startegies for both the mother and the baby. Osteoporosis research is directed toward better understanding the biomechanical factors responsible for fracture and failure of bone to withstand minimal trauma. Diagnostic tools need to be developed that better identify those patients most likely to benefit from interventional strategies aimed at reducing fracture incidence.
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