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| Dr David Connor
St Vincent's Clinical SchoolStatement of Interests:
Flow cytometric detection of platelet function and microparticle enumeration, currently in the context of bleeding disorders.
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| Dr Xing-Mai Jiang
St George Clinical SchoolStatement of Interests:
Autoimmune thrombocytopenia is a common complication of therapy with a large number of drugs. In most cases, antibodies bind to the platelet membrane glycoprotein (GP) Ib-IX complex in a drug-dependant fashion and bring about increased platelet clearance by the reticuloendothelial system resulting in drug-induced thrombocytopenia (DIT). The binding sites of GPIX-specific quinine-induced antibodies have been located in this lab. By using recombinant and soluble GPIba, Ibb, and GPIX protein fragments, models on drug-to-GPIb/IX, and antibody-to-GPIb/IX binding can be set up to demonstrate the molecular and structural bases of HIT, DIT, and ITP.
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| Professor Steven Krilis
St George Clinical School - Department of MedicineStatement of Interests:
Research in the Department has focussed on 2 broad areas, autoimmune disease and mast cell biology. In the autoimmune area, animal experiments designed to elucidate the cause of thrombosis and miscarriage in women with the antiphospholipid syndrome. The assessment of Beta 2-glycoprotein I function in humans and experiments utilising beta 2-GPI knockout mice that have been derived in the Department. Epitope mapping of autoantibodies from patients with recurrent miscarriage and thrombosis. Collaborative work with researchers at the Harvard University, Boston, USA, Tianjin University, Tianjin, China, University of Brest, France, Sapporo University, Japan and University of Athens, Greece, University of Pennsylvania and the NIH, USA. The role of Beta 2-glycoprotein I in in-vitro and in-vivo angiogenesis is currently being investigated using a Matrigel and tumour animal models with Beta 2GPI knockout mice. The role of Beta 2GPI in cholesterol metabolism is being assessed using C57BL/6 Beta 2GPI+/+ and -/- mice fed a western diet. The 2nd area is involved with mast cells and their effect in asthma. Cloning and generating knockout mice of a novel mast cell specific RasGRP4. RasGRP4 knockout mice have defects in mast cell differentiation and expression of FcεR1 and c-Kit. Defining gene mutations in patients with mastocytosis, asthma and rheumatoid arthritis. Identifying the receptor on mast cells for IL-16. The role of mast cells and basophils in HIV-1 infection. Collaborative work with biologists at the Millennium Institute at Westmead is concerned with HIV-1 infection in mast cells and basophils and with biologists at the Harvard Medical School, Boston, USA is concerned with elucidation of the role of mast cell specific proteases in inflammation, asthma and cancer.
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| Dr Helena Liang
UNSW Cancer Research Centre | |
| Associate Professor Richard Lock
School of Women's and Children's HealthStatement of Interests:
In the field of cancer the major focus is in defining molecular mechanisms of drug resistance in relapsed childhood leukaemia. New experimental models of childhood acute lymphoblastic leukaemia have been developed that will be used to delineate mechanisms of programmed cell death (apoptosis) and investigate novel biological characteristics of the disease. In addition, these experimental models will be used test novel therapeutic agents/strategies for management of the high-risk or relapsed patient.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Dr Mark Lutherborrow[</b><br>    <i>St Vincent's Clinical Sch](/icons/expand.gif) Dr Mark Lutherborrow
St Vincent's Clinical School - Blood Stem Cells and Cancer ResearchStatement of Interests:
My research interests are projects centred on transcription networks operating in haematopoietic malignancies and stem cells, in particular the interplay of mRNAs and microRNAs in the acute leukaemia setting. More specifically these interests include: - Identification of diagnostic and prognostic gene expression profiles in Acute Myeloid Leukaemia. - The role of microRNAs in myeloid differentiation. - Characterisation of the response of multiple myeloma cells to chemotherapeutic agents. - Predictive techniques to identify mRNA targets of microRNAs
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| Dr Karen MacKenzie
School of Women's and Children's HealthStatement of Interests:
Molecular mechanisms that control cell proliferation, and promote immortalisation and tumorigenic conversion of human cells, including haematopoietic stem and mesenchymal cells. Current research is focussed on the role of telomeres, telomerase, oncogenes, tumour suppressor genes and antiapoptotic pathways in carcinogenesis and haematopoiesis.
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| Dr Jose Perdomo
Centre for Vascular ResearchStatement of Interests:
Dr Perdomo's interest is the post-translational modifications of transcription factors that regulate the commitment and differentiation of haematopoietic cells, especially megakaryocytes (the precursors of platelets) and erythrocytes (red blood cells). Of special interest is the modification of transcription factors by a small protein called SUMO. Modification with SUMO typically alters the function of target protein leading to important biological consequences such as differential gene expression. His main research interests are:- Identification of SUMO-modified proteins in megakaryocytes and erythroid cells; - Analysis of the role played by SUMO-modified proteins in cellular differentiation and proliferation; - The role of transcription factors in blood disorders such as thrombocythemia and polycythemia. Knowledge gained from this research will help elucidate fundamental aspects of blood development.
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| Dr John Pimanda
Prince of Wales Clinical SchoolStatement of Interests:
Haematopoietic Stem Cells (HSCs) represent the best characterized adult multipotent stem cell population. Transcriptional regulation is a key mechanism controlling the formation and subsequent behaviour of HSCs. To investigate gene regulatory networks that operate during HSC specification, we use computational tools to predict regulatory elements of key haematopoietic transcription factor genes. We then filter these predictions using array based chromatin accessibility and transcription factor binding profiles. Transgenic mice are generated to test whether these predicted elements show tissue specific activity in the developing embryo. We also investigate mesenchymal stem/progenitor cell (MSCs)development to compare and contrast gene transcription between HSCs and MSCs. Knowledge of the normal transcriptional hierarchies of these cell types can be applied to better understand the dysregulation of these networks in the pathogenesis of cancer. To this end, we also study the biology of blood stem cell dyscrasias with a particular focus on the myelodysplastic and myeloproliferative syndromes.
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| Associate Professor Bill Sewell
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Major interest is molecular and cellular biology of allergic inflammation. Particular interests are: (1) Role of cytokines, including Th2 cytokines and GM-CSF, in the pathogenesis of asthma, other allergic diseases and parasite infection; (2) Role of eosinophils in these conditions; (3) In collaboration with A/Prof Andrew Collins, Biotechnology and Biomolecular Sciences, UNSW, investigation of immunoglobulin E sequences in allergy and parasitic infection; (4) In collaboration with the Pathology Department in St Vincent's Hospital, investigation of novel markers in leukaemia and lymphoma.
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| Dr David Ziegler
School of Women's and Children's HealthStatement of Interests:
David Ziegler's research interest is in the translation of novel targeted therapeutics from the laboratory to the bedside. He received a Fulbright Scholarship to attend the Dana Farber Cancer Institute, where he discovered novel combination therapies that target the apoptotic pathway in malignant gliomas. He is currently pursuing these research findings in collaboration with Prof Michelle Haber at the Children's Cancer Institute, Australia. He has established an early phase clinical trials unit at Sydney Children's Hospital to facilitate the translation of laboratory findings to the clinic.
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