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| Dr Alison Butt
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Human cancers are characterised by a disruption of normal cellular growth due to defects in the control of both cell proliferation and cell death (apoptosis). Apoptosis is a physiological form of cell death with distinct morphological and biochemical characteristics. Current therapies for the treatment of human cancers, including ionising radiation and chemotherapeutic drugs, kill tumour cells by inducing apoptosis, so understanding how the process of cell death is regulated in normal and cancerous cells is an important goal for effective treatment. Current projects include defining the molecular mechanisms of estrogen- and antiestrogen-mediated survival/apoptosis in breast cancer models and characterising the apoptotic effects of novel therapeutics for breast cancer.
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| Dr Hui Chen
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The effects of maternal nutrition interventions on appetite, body weight, hormones (plasma leptin, insulin), lipids, and brain peptide expression invovled in appetite and glucose metabolism in offspring are of interest. A palatable high fat diet (32% fat) is being used to induce maternal obesity. This approach will be used to address the possibility of preventing childhood obesity by drugs and behaviour interventions. A second area of study deals with the effects of cigarette smoking on appetite, body weight, plasma leptin, and hypothalamic peptides expression to address wasting diseases.
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| Associate Professor Maria Craig
School of Women's and Children's HealthStatement of Interests:
My major research interest is childhood diabetes, including the association between enteroviruses and type 1 diabetes (in collaboration with the Virology Research Group at POWH, headed by Prof W Rawlinson) and the epidemiology of childhood diabetes (type 1 and type 2). I am also actively involved in research into diabetes complications (in collaboration with Assoc Prof Kim Donaghue at the Children's Hospital at Westmead).
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| Associate Professor John Eden
School of Women's and Children's HealthStatement of Interests:
Associate Professor Eden is actively involved in the following areas of Research: 1) The polycystic ovary syndrome: It's Aetiology, Pathogenesis, Diagnosis, Prevalence, Inheritance, Infertility & recurrent abortion, and Treatment; 2) Anovulation, including Weight-loss, Exercise-induced, Health risks, Ovulation induction, and Diet & reproduction; 3) Regulation of the ovary including Paracrine control, Insulin-like growth factors and Other peptide growth factors; 4)Menopause issues of Hormone replacement, Osteoporosis, Progestogens, Education, Breast cancer, Cancer and HRT, Diet and menopausal symptoms, and Phytoestrogens; 5) Nutrition topics such as Functional foods, Over-the-counter products, Cancer treatment and prevention, Lipid lowering, Cardiovascular disease treatment and prevention, Menopause syndrome, Isoflavones, and Lignans 6) Microbiological Biofilms in health and sickness
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| Dr Jeff Flack
South Western Sydney Clinical School - Department of MedicineStatement of Interests:
My main area of research interest is in Datasets and Quality Audit & Benchmarking in Diabetes utilising Computer Technologies.
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| Dr Jenny Gunton
St Vincent's Clinical SchoolStatement of Interests:
Diabetes develops when the beta-cells in the pancreas are no longer able to make enough insulin to control blood glucose levels. My research interest is to understand the mechanisms behind beta-cell failure in type 1 diabetes (childhood onset / IDDM), type 2 diabetes (adult-onset / NIDDM) and diabetes in pregnancy (Gestational Diabetes).
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| Emeritus Scientia Professor Eugenie Lumbers
School of Medical Sciences - Department of PhysiologyStatement of Interests:
fetal origins of adult disease, hypertension , development of control of the circulation, renin-angiotensin system, effects on the autonomic control of the circulation, renal development and function, placental function and the placental and renal prorenin/renin systems, preterm labour, programming for renal and cardiovascular disease
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| Professor Elizabeth Musgrove
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Major research interest is understanding the control of cell cycle progression in breast cancer cells, in particular the molecular mechanisms by which steroid hormones (oestrogen and progesterone) regulate this process.
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| Professor Tuan Van Nguyen
School of Public Health and Community MedicineStatement of Interests:
I have two main interests in osteoporosis research: epidemiology of osteoporotic fractures and genetics of osteoporosis. In terms of epidemiology, my group’s research interests are mainly in the study of determinants of fracture and the development of prognostic models for predicting fracture risk in an individual patient. A second focus of my group’s research is concerned with the genetics of osteoporosis. We are specifically interested in finding novel genes that are involved in the regulation of bone phenotypes, including bone mineral density and fracture. Current research projects: * Development of prognostic models for the assessment of fracture risk * Development of new phenotype for osteoporosis * Determinants of bone loss and the concept of risk individualization * Hormonal determinants of diabetes, cancer and osteoporosis * Bayesian models for epidemiologic data * Genomewide association study of osteoporosis genes * Genomewide linkage analysis of bone phenotypes I currently have a number of projects that are suitable for masters and PhD candidates. I am looking for candidates with strong background in clinical epidemiology, genetics, and biostatistics with solid knowledge in Bayesian modeling. Interested candidates can contact me via email at tuan.nguyen@unsw.edu.au or t.nguyen@garvan.org.au for more detailed description of these projects.
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| Associate Professor Tony O'Sullivan
St George Clinical School - Department of MedicineStatement of Interests:
Current research includes: - regulation of fat mass in premenopausal and pregnant women, substrate metabolism in pregnancy; hormonal regulation of energy metabolism and body composition - sex steroid regulation of substrate metabolism - anabolic steroid use - energy metabolism and body composition in chronic medical illnesses, eg chronic renal failure & insulin resistance
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| Dr Charles Verge
School of Women's and Children's HealthStatement of Interests:
(1) Early diagnosis of insulin deficiency (and diabetes) in children and adolescents with cystic fibrosis (2) Studies on the duration of adrenal suppression following prednisone treatment, using the return of diurnal variation in salivary cortisol levels as the main outcome (3) Randomised controlled trials in the management of children/adolescents with type I diabetes (4) Monogenic diabetes
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