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| Dr Yew-Wee Chua
School of Women's and Children's HealthStatement of Interests:
In the field of paediatric allergy, the relationship between skin prick testing and risk of clinical anaphylaxis.
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| Dr Cristan Herbert
School of Medical Sciences - Department of PathologyStatement of Interests:
Asthma and in vivo models of the disease. Specific interest in the role of Th17 cell cytokines in the development of airway wall remodelling. Also interested in the effect of novel drug treatments on asthmatic lesions.
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| Dr John Hunt
School of Medical Sciences - Department of PathologyStatement of Interests:
My research interests focus on mast cell biology and the discovery and molecular characterisation of novel mast cell proteases. We have recently discovered a number of novel human mast cell tryptases, and we are currently determining their substrate specificity. Another aspect of our work involves the characterisation of factors that control the biology of mast cells. We have demonstrated that IL-15 is one of the most potent mast cell attractants yet reported, and aslo acts to upregulate the expression of ubiquitin-protein ligase 3B, matrix metalloproteinase 9 (MMP9) and apolipoprotein CI (ApoC1) by mast cells.
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| Professor Steven Krilis
St George Clinical School - Department of MedicineStatement of Interests:
Research in the Department has focussed on 2 broad areas, autoimmune disease and mast cell biology. In the autoimmune area, animal experiments designed to elucidate the cause of thrombosis and miscarriage in women with the antiphospholipid syndrome. The assessment of Beta 2-glycoprotein I function in humans and experiments utilising beta 2-GPI knockout mice that have been derived in the Department. Epitope mapping of autoantibodies from patients with recurrent miscarriage and thrombosis. Collaborative work with researchers at the Harvard University, Boston, USA, Tianjin University, Tianjin, China, University of Brest, France, Sapporo University, Japan and University of Athens, Greece, University of Pennsylvania and the NIH, USA. The role of Beta 2-glycoprotein I in in-vitro and in-vivo angiogenesis is currently being investigated using a Matrigel and tumour animal models with Beta 2GPI knockout mice. The role of Beta 2GPI in cholesterol metabolism is being assessed using C57BL/6 Beta 2GPI+/+ and -/- mice fed a western diet. The 2nd area is involved with mast cells and their effect in asthma. Cloning and generating knockout mice of a novel mast cell specific RasGRP4. RasGRP4 knockout mice have defects in mast cell differentiation and expression of FcεR1 and c-Kit. Defining gene mutations in patients with mastocytosis, asthma and rheumatoid arthritis. Identifying the receptor on mast cells for IL-16. The role of mast cells and basophils in HIV-1 infection. Collaborative work with biologists at the Millennium Institute at Westmead is concerned with HIV-1 infection in mast cells and basophils and with biologists at the Harvard Medical School, Boston, USA is concerned with elucidation of the role of mast cell specific proteases in inflammation, asthma and cancer.
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| Professor Rakesh Kumar
School of Medical Sciences - Department of PathologyStatement of Interests:
In vivo and in vitro models of the cellular biology and immunopathology of respiratory disease. Major focus is the role of cytokines and growth factors in the pathogenesis of chronic asthma and acute exacerbations, using novel experimental models in mice. Ongoing collaborations with colleagues at the University of Newcastle/Australian National University, using gene-targeted mice and drug/antibody treatments to study the contribution of specific cytokines to inflammation, remodelling and airway hyper-reactivity; and the influence of early-life infections on the severity of chronic disease and susceptibility to acute exacerbations. Expertise in morphometry and immunohistochemistry has led to involvement in various other collaborative projects e.g. related to pancreatic disease and hepatitis.
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| Dr Daniel Avi Lemberg
School of Women's and Children's HealthStatement of Interests:
Non-Alcoholic liver disease (NAFLD) is a term to describe liver damage in obese patients. Currently while their is information as to the inflammatory cascade set-up in this entity; in a collaboration with colleagues at the University of British Columbia (UBC) we are investigating possible pathways that trigger this cascade. There continues to be great uncertainty as to the cause of The Inflammatory Bowel Diseases in children. In collaboration with collleagues at UNSW and UBC we aim to study demographic trends in children with IBD in particular Crohn's Disease and possible microbiological or environmental triggers for this illness.
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| Professor Patrick McNeil
South Western Sydney Clinical School - Department of MedicineStatement of Interests:
Patrick McNeil heads a research group exploring mast cell biology and novel inflammatory pathways in rheumatoid arthritis and autoimmune connective tissue diseases, especially focusing on molecular mechanisms of inflammation. He has a long term focus on mast cell proteinases including characterisation of novel human tryptase genes, and the role of mast cell proteinases in rheumatoid arthritis. More recently he has research programs investigating expression of LLIR's in rheumatoid arthritis, and cardiovascular disease in rheumatoid arthritis.
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| Associate Professor Bill Sewell
St Vincent's Clinical School - Department of MedicineStatement of Interests:
Major interest is molecular and cellular biology of allergic inflammation. Particular interests are: (1) Role of cytokines, including Th2 cytokines and GM-CSF, in the pathogenesis of asthma, other allergic diseases and parasite infection; (2) Role of eosinophils in these conditions; (3) In collaboration with A/Prof Andrew Collins, Biotechnology and Biomolecular Sciences, UNSW, investigation of immunoglobulin E sequences in allergy and parasitic infection; (4) In collaboration with the Pathology Department in St Vincent's Hospital, investigation of novel markers in leukaemia and lymphoma.
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| Professor Paul Thomas
Prince of Wales Clinical School - Department of MedicineStatement of Interests:
Innovative research has emerged from our studies on non-invasive methods of studying airway diseases. We have shown that exhaled nitric oxide is a method by which we can monitor lung diseases such as asthma. In addition, we are studying methods of detecting and monitoring lung diseases such as COPD and lung cancer by using breath analysis. In addition, there is the opportunity to start novel projects in sarcoidosis and the ways in which the lung is affected by diving. The research techniques range from basic molecular biology to clinical trials in the above areas. All the above studies are supported by competitive research grants and any interest in research in the above areas will be encouraged. Many peer-reviewed publications have arisen from these projects, and any participation would be expected to generate presentations and manuscripts. Most ILP students have gained at least one journal article during their study period, while other candidates have achieved more than this.
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