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Research InterestsProfessor Paul Thomas | | (Position Details) | | Phone 02 9382 4620 | | Email | | Qualifications BSc (Pharm) MB BS MD Lond, FRCP, FRACP |
| | | School/Unit |
| Prince of Wales Clinical School | |
| | Broad Research Areas | |
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Allergy
Inflammation
Pulmonary Disease
Medical Education
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| | | | Specific Research Keywords | |
| Asthma
Peer Learning
Lung Cancer
Mast cells
Sarcoidosis
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| | | | Research Interests | |
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Innovative research has emerged from our studies on non-invasive methods of studying airway diseases. We have shown that exhaled nitric oxide is a method by which we can monitor lung diseases such as asthma. In addition, we are studying methods of detecting and monitoring lung diseases such as COPD and lung cancer by using breath analysis. In addition, there is the opportunity to start novel projects in sarcoidosis and the ways in which the lung is affected by diving. The research techniques range from basic molecular biology to clinical trials in the above areas. All the above studies are supported by competitive research grants and any interest in research in the above areas will be encouraged. Many peer-reviewed publications have arisen from these projects, and any participation would be expected to generate presentations and manuscripts. Most ILP students have gained at least one journal article during their study period, while other candidates have achieved more than this.
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| | | | ILP Research Interests (Will supervise ILP students) |
| Lung Diseases
Respiratory Tract Diseases
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| | | | Project Topics for current Honours Students |
| Exhaled breath analysis applied to COPD asthma and lung cancer. | |
| | | | Teaching Interests | |
| Successful peer-teaching programmes have been established here at POWH CLinical School, both with Year III peer-pairs and with Year VI tutors teaching Year III groups. These have significantly enhanced the performance of the recipients and have had benefits for the tutors. Any interest in studying this area would be appreciated. | |
| | | | Society Memberships & Professional Activities | |
| American Thoracic Society
British Thoracic Society
Thoracic Society of ANZ
British Medical Association
Asia Pacific Society of Respirology
South Pacific Underwater Medicine Society | |
| | | | Funding Sources | |
| NH&MRC
Asthma Foundation of NSW
Dust diseases (Workers'Compensation) Board of NSW
Ramaciotti Foundation
Viertel Foundation | |
| | | | Other Postgraduate Research | |
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Current Honours students and PhD students are undertaking work in the areas of both basic science and in clinical medicine.
The Honours projects will appeal to those with an interest in clinical science and medicine, particularly those who will be applying for courses in Medicine after their Honours year. The projects will allow interaction with patients, medical students and other hospital staff, so that the candidates will gain an insight into what it is like to be a medical student and a doctor. The research will be focussed, with the intention of building up a research portfolio of skills and publications. Candidates interested in pursuing a medical career will be assisted in their endeavours.
Higher degree candidates (PhD, MD, Masters) will be able to choose from the range of bench to bedside research topics. These will generally be in the range of respiratory medicine, allergy/inflammation, asthma, exhaled gas analysis, changes in lung function at depth and during diving. Particular interests are asthma, mast cell biology, and sarcoidosis. These topics are particulary suitable for those with the career goal of a teaching hospital or university appointment. | |
| | | | Key works/Publications | |
| 1. Liu J, Thomas PS. Exhaled breath condensate as a method of sampling airway nitric oxide and other markers of inflammation. Med Sci Monitor 2005; MT53-62.
2. Wei XM, Kim HS, Kumar RK, Heywood GJ, McNeil HP, Thomas PS. Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells. Respiratory Research 2005; 6: 108.
3. Bruce C, Heywood G, Thomas PS. Effect of the metalloproteinase inhibitor, marimastat, upon allergic asthma. Toxicology and Applied Pharmacology 2005, 205 126-132.
4. Ratnawati, Thomas PS. Exhaled nitric oxide in paediatric asthma. J Chronic Lung Disease 2005; 2: 163-174.
5. Thomas PS*#, Henry R, Shah S, Gibson PG. Exhaled nitric oxide as a marker for asthma in adolescent children. J Asthma (in press 2005)
6. Liangas G, Yates DH, Henry R, Thomas PS. Laughter as a risk factor for asthma. J Asthma 2004; 41(2): 217-222.
7. *Thomas, P.S., Yates, D.H. A new nose for the diagnosis of diseases. ChemoSense 2003, 5(4), 9-11.
8. Kumar RK, Herbert C, Thomas PS*$, Wollin L, Beume R, Yang M, Dianne C, Webb DC, Foster PS. Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma. J Pharm Exp Ther 2003; 307: 349-55.
9. Bruce C, Sanger M, Thomas PS, Petkus JR, Yates DH. Factors affecting consultant stress in an Australian Teaching Hospital: a comparison between women and men. Med J Aust 2003; 179: 174-9.
10. Shaw J, Harris P, Keogh G, Graudins L, Perks E, Thomas PS*#. Error reduction: using academic detailing to improve prescribing. Eur J Clin Pharmacol 2003; 59: 697-9.
11. Wei XM, Heywood G, DiGirolamo N, Thomas PS*#. Nicorandil modulates the secretion of TNF alpha from lymphocytes. Immunopharmcol 2003; 3:1581-8
12. Wang HW, McNeil HP, Husain A, Liu K, Tedla N, Thomas PS*$, Raftery M, King GC, Cai ZY, Hunt JE. Delta Tryptase Is Expressed in Multiple Human Tissues, and a Recombinant Form Has Proteolytic Activity. J Immunol 2002 169: 5145-5152.
13. Kumar RK, Thomas PS*$, Wang ST, Herbert C, McKenzie ANJ, Foster P, Lloyd A. Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma. Laboratory Investigation. 2002; 82: 495-504
14. Bruce C, Yates DH, Thomas PS*#. Stress and ill-health in junior medical staff. Internal Medicine 2002; 33:392-5.
15. Thomas P*#,, Ng C, Trytko B, Bennett M. Effects of hyperbaric oxygen therapy on lung volumes in normal subjects and heavy smokers. South Pacific Underwater Medicine Journal 2002; 32(1):50-53.
16. Thomas PS*#, Tan KS, Yates DH. Influence of funding upon outcomes of research in asthma and rhinitis. Lancet 2002; 359:351.
17. Bruce C, Yates DH, Thomas PS*#. Caffeine and nitric oxide. Thorax (accepted 2002, letter)
18. Thomas PS*#, Harris P, Rendina N, Keogh G. Residents as teachers: outcomes of a brief training programme. Education for Health 2002; 15:71-78.
19. Yates DH, Thomas PS*#. Passive smoke and exhaled nitric oxide. Am. J. Respir. Crit. Care Med. 2002 165, 2002, 1188-1188 (letter).
20. Thomas PS*#, Heywood G. Effects of inhaled tumor necrosis factor alpha in subjects with mild asthma. Thorax 2002; 57: 774-778.
21. Thomas PS*#. Lung function testing to detect asthma in divers. S Pacific Underwater Medicine Society J 2001; 31: 229-232.
22. Heywood G, Thomas PS*#. Effects of inhaled tumor necrosis factor alpha in subjects with mild asthma. Thorax 2002; 57: 774-778.
23. 2. Thomas PS*#, Bruce C, Birkhead A, Wang XL. Effect of ecNOS polymorphisms and coronary artery disease. J Molec Med 2002; 80: 181-186.
24. 3. Heywood G, Thomas PS*#. Nicorandil inhibits degranulation and TNF alpha release by RBL-2H3 cells. Inflammation Research 2002; 51: 176-181.
25. 4. Yates DH, Breen H, Thomas PS*#. Passive smoke inhalation decreases exhaled nitric oxide in normal subjects. Am J Respir Crit Care Med 2001; 164: 1043-1046.
26. 5. Thomas PS*#. Tumour necrosis factor alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 2001; 79: 132-40.
27. 6. Thomas PS#, Pennington DW, Schreck RE, Levine T, Lazarus SC. Authentic 17kD tumor necrosis factor alpha is synthesized and released from canine mast cells and up-regulated by stem cell factor. Clinical and Experimental Allergy 1996; 26: 710-718.
28. 7. Thomas PS#, Yates DH, Barnes PJ. Tumor necrosis factor alpha increases airway and sputum neutrophilia in normal subjects. Am J Respir Crit Care Med 1995; 152: 76-80.
29. 8. Yates DH, Kharitonov SA, Robbins RA, Thomas PS$, Barnes PJ. Effect of a nitric oxide inhibitor and a glucocorticoid on exhaled nitric oxide. Am J Respir Crit Care Med 1995; 152: 892-896.
30. 9. Pennington DW, Lopez AR, Thomas PS$, Peck C, Gold WM. Dog mastocytoma cells produce transforming growth factor beta1. J Clin Invest 1992; 90: 34-41.
31. 10. Thomas PS#, Wilson AN, Lazarus SC. Prostaglandin D2 production and identification of prostaglandin H synthase within the mast cell granule. Am J Physiol: Lung Cell Mol Physiol 1992; 263: L 168-L176.
32. 11. Thomas PS#, Schreck RE, Lazarus SC. Cigarette smoke induces mast cell activation. Am J Physiol: Lung Cell Mol Physiol 1992; 263: L670-L72.
33. 12. Thomas PS#, Schreck RE, Ruoss SJ, Lazarus SC. Heterogeneity of intact granules purified from canine mastocytoma cell lines. Am J Physiol: Lung Cell Mol Physiol. 1991; 260: L153 -160. | |
| | | | Attachments | |
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Publication list 11.08.doc | |
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