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Research InterestsProfessor Elizabeth Burcher | | (Position Details) | | Phone 02 9385 2562 | | Email | | Qualifications BSc Edin, PhD UNSW |
| | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Gastrointestinal Diseases
Pharmacology
Neuroscience
Ageing
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| | | | Specific Research Keywords | |
| Bladder
Colon
G-protein Coupled Receptors
Neuropeptides
Non-mammalian Pharmacology
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| | | | Research Interests | |
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a) neurochemicals in human intestine: alterations in disease. b) neurochemicals in the human bladder: relevance to urinary incontinence. c) urothelium of the pig bladder as a model for human bladder studies.
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| | | | Society Memberships & Professional Activities | |
| Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Member of Council, Membership Secretary.
Australian Neuroscience Society (ANS)
European Neuropeptide Club
International Continence Society (ICS) | |
| | | | Funding Sources | |
| NH&MRC
Australasian Urological Foundation
NSW Govt Office of Science and Medical Research
Rebecca Cooper Medical Research Foundation
Pfizer OAB-LUTS Program | |
| | | | Key works/Publications | |
| Lee, C.M., Kumar, R., Lubowski, D.Z. & Burcher, E. (2002) Neuropeptides and nerve growth in inflammatory bowel diseases: A quantitative immunohistochemical study. Dig. Dis. Sci. 47, 495-502.
Liu, L., Shang, F., Markus, I. & Burcher, E. (2002) Role of substance P in the human colon: alterations in disease. J. Pharmacol. Exp. Ther. 302, 627-635.
Warner, F.W., Shang, F., Millard, R.J. & Burcher, E. (2002) Enhancement of neurokinin A-induced smooth muscle contraction in human urinary bladder by mucosal removal and phosphoramidon: relationship to peptidase inhibition. Eur. J. Pharmacol. 438, 171-177.
Liu, L., Markus, I., Vandenberg, R.J., Neilan, B.A., Murray, M. & Burcher, E. (2004) Molecular identification and characterization of three isoforms of tachykinin NK1-like receptors in the cane toad, Bufo marinus. Am. J. Physiol. Reg. Int. Comp. 287, R575-585.
Mansfield, K.J., Liu, L., Mitchelson, F.J., Moore, K.H., Millard, R.J. & Burcher, E. (2005) Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: Changes in ageing. Br. J. Pharmacol. 144, 1089−1099.
Liu, L., Mansfield, K.J., Kristiana, I., Vaux, K.J., Millard, R.J. & Burcher, E. (2007) The molecular basis of urgency: Regional difference of vanilloid receptor expression in the human urinary bladder. Neurology & Urodynamics 26, 433-438.
Burcher E, Shang F, Warner FJ, Du Q, Lubowski DZ, King DW, Liu L (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. J. Pharmacol. Exp. Ther. 324, 170-178.
Sadananda, P., Chess-Williams, R., Burcher, E. (2008) Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts? Br J Pharmacol 153, 1465-1473.
Mansfield, K.J., Chandran, J.J., Vaux, K.J., Millard, R.J., Christopoulos, A., Mitchelson, F.J., Burcher, E. (2009) Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. J. Pharmacol. Exp. Ther. 328, 893-899.
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| | | | Attachments | |
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Burcher publications recent.htm | |
| | | | Further Information | |
| http://medicalsciences.med.unsw.edu.au/somsweb.nsf/page/Neurochemicals+in+the+peripheral+nervous+system | |
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