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Research InterestsProfessor Nick Hawkins | | (Position Details) | | Phone 02 9385 2531 | | Email | | Qualifications MB BS PhD MHEd UNSW, FRCPA |
| | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Gastrointestinal Diseases
Gastrointestinal Diseases
Pathology
Medical Education
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| | | | Specific Research Keywords | |
| Histopathology
Colorectal cancer
Gastrointestinal Diseases
Molecular Oncology
Epigenetics
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| | | | Research Interests | |
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In terms of colorectal (bowel) cancer, the work of the laboratory is focussed on understanding the molecular changes that drive the process of cancer development. There is an emphasis on the role of DNA methylation in the development of bowel cancer, and on the correlation between microscopic appearances of cancer, and the key genetic changes occuring in the tumour.
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| | | | Teaching Interests | |
| A broad interest is in the teaching of pathology to undergraduate medical and science students, with an emphasis on the development of integrated, experiential and self-directed learning structures. A longstanding interest in the application of computers to undergraduate medical education, particularly with regard to the development of interactive databases of images used commonly in the teaching of Pathology. | |
| | | | Society Memberships & Professional Activities | |
| Royal College of Pathologists of Australasia
Australian Gastrointestinal Trials Group
American Association for Cancer Research | |
| | | | Funding Sources | |
| Support for research activities is provided by grants from the NH&MRC, NSW State Cancer Council and the Cancer Institute of NSW. | |
| | | | Other Postgraduate Research | |
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| | | | Key works/Publications | |
| Publications in last 5 years
Wong JJL, Hawkins NJ, Ward RL. Colorectal cancer - a model for epigenetic tumorigenesis. Gut. 2006.
Hitchins M, Suter C, Wong J, Cheong K, Hawkins N, Leggett B, et al. Germline epimutations of APC are not associated with inherited colorectal polyposis. Gut. 2006;55:586-7.
Hitchins M, Williams R, Cheong K, Halani N, Lin VA, Packham D, et al. MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology. 2005;129:1392-9.
Ward RL, Turner J, Williams R, Pekarsky B, Packham D, Velickovic M, et al. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol. 2005;207:377-84.
Ward RL, Williams R, Law M, Hawkins NJ. The CpG island methylator phenotype is not associated with a personal or family history of cancer. Cancer Res. 2004;64:7618-21.
Ward RL, Cheong K, Ku SL, Meagher A, O'Connor T, Hawkins NJ. Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol. 2003;21:3729-36.
Brown DA, Ward RL, Buckhaults P, Liu T, Romans KE, Hawkins NJ, et al. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res. 2003;9:2642-50.
Norrie MW, Hawkins NJ, Todd AV, Meagher AP, O'Connor TW, Ward RL. Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer. J Surg Oncol. 2003;84:143-50.
Welsh JB, Sapinoso LM, Kern SG, Brown DA, Liu T, Bauskin AR, et al. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A. 2003;100:3410-5.
Bariol C, Suter C, Cheong K, Ku SL, Meagher A, Hawkins N, et al. The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol. 2003;162:1361-71.
Bariol C, Hawkins NJ, Turner JJ, Meagher AP, Williams DB, Ward RL. Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod Pathol. 2003;16:417-23.
Quinn E, Hawkins N, Yip YL, Suter C, Ward R. CD103+ intraepithelial lymphocytes--a unique population in microsatellite unstable sporadic colorectal cancer. Eur J Cancer. 2003;39:469-75.
Norrie MW, Cheong K, Ku S, Mokany E, Todd AV, O'Connor T, et al. Gene hypermethylation is a major determinant of phenotypic expression in colorectal cancer. Gastroenterology. 2002;122:804-5.
Tomlinson I, Halford S, Aaltonen L, Hawkins N, Ward R. Does MSI-low exist? J Pathol. 2002;197:6-13.
Hawkins NJ, Bariol C, Ward RL. The serrated neoplasia pathway. Pathology. 2002;34:548-55.
Ward R, Meldrum C, Williams R, Mokany E, Scott R, Turner J, et al. Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer. J Cancer Res Clin Oncol. 2002;128:403-11.
Hawkins N, Norrie M, Cheong K, Mokany E, Ku SL, Meagher A, et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology. 2002;122:1376-87.
Morey AL, Wanigesekera GD, Hawkins NJ, Ward RL. C-kit mutations in gastrointestinal stromal tumours. Pathology. 2002;34:315-9.
Suter CM, Morgan G, Hanby A, Hawkins NJ, Ward RL. Clinicopathological correlates of GpIbalpha expression in human breast cancers. Anticancer Res. 2002;22:1251-5.
Halford S, Sasieni P, Rowan A, Wasan H, Bodmer W, Talbot I, et al. Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. Cancer Res. 2002;62:53-7.
Ward RL, Hawkins NJ. Medical oncology. Med J Aust. 2002;176:25.
Davenport MP, Ward RL, Hawkins NJ. The null oncogene hypothesis and protection from cancer. J Med Genet. 2002;39:12-4.
Norrie MW, Hawkins NJ, Todd AV, Meagher AP, O'Connor TW, Ward RL. The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas. Dis Colon Rectum. 2002;45:674-80.
Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst. 2001;93:1307-13.
Hawkins NJ, Tomlinson I, Ward R, Jass JR, Young J, Leggett BA. Biological significance of microsatellite instability-low (MSI-L) status in colorectal tumors. Am J Pathol. 2001;158:779-81.
Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 2001;85:692-6.
Ward R, Meagher A, Tomlinson I, O'Connor T, Norrie M, Wu R, et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut. 2001;48:821-9.
Ward RL, Hawkins NJ. Checking the scoreboard: the impact of cancer genetics on clinical practice. Intern Med J. 2001;31:249-53.
Hawkins NJ, Tomlinson I, Meagher A, Ward RL. Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. Br J Cancer. 2001;84:232-6.
Ward RL, Packham D, Smythe AM, Murray J, Anderson-Stewart P, Kitchen N, et al. Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer. Clin Cancer Res. 2000;6:4674-83.
Hawkins NJ, Gorman P, Tomlinson IP, Bullpitt P, Ward RL. Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway. Am J Pathol. 2000;157:385-92.
Ward R, Sheehan C, Norrie M, Applegate T, Fuery C, Impey H, et al. Factors influencing the detection of mutant K-ras in the serum of patients with colorectal cancer. Ann N Y Acad Sci. 2000;906:17-8.
Fuery CJ, Impey HL, Roberts NJ, Applegate TL, Ward RL, Hawkins NJ, et al. Detection of rare mutant alleles by restriction endonuclease-mediated selective-PCR: assay design and optimization. Clin Chem. 2000;46:620-4. | |
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