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Research InterestsDr John Hunt | | (Position Details) | | Phone 02 9385 1580 | | Email | | Qualifications BSc Hons Syd, PhD UNSW |
| | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Allergy
Biochemistry
Genetics - Genome Analysis
Immunology
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| | | | Specific Research Keywords | |
| Inflammation
Protease
Genome search
mast cell biology
Tryptase
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| | | | Research Interests | |
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My research interests focus on mast cell biology and the discovery and molecular characterisation of novel mast cell proteases. We have recently discovered a number of novel human mast cell tryptases, and we are currently determining their substrate specificity. Another aspect of our work involves the characterisation of factors that control the biology of mast cells. We have demonstrated that IL-15 is one of the most potent mast cell attractants yet reported, and aslo acts to upregulate the expression of ubiquitin-protein ligase 3B, matrix metalloproteinase 9 (MMP9) and apolipoprotein CI (ApoC1) by mast cells.
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| | | | ILP Research Interests (Will supervise ILP students) |
| Amino Acids/Peptides And Proteins
Biochemistry
Inflammation
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| | | | Teaching Interests | |
| My teaching interests include molecular biology, biochemistry of proteases and immunology, and small group teaching in Phase 1 medicine. Presently I supervise or co-supervise one PhD student and an ILP student. In past years I have supervised a number of honours students | |
| | | | Society Memberships & Professional Activities | |
| ASMR | |
| | | | Funding Sources | |
| - NHMRC (project grants)
- ARC (linkage)
- UNSW capital grant
- Industry: Sanofi-Aventis Pharamaceuticals | |
| | | | Key works/Publications | |
| 1. Jackson NE, Wang HW, Tedla N, McNeil HP, Geczy CL, Collins A, Grimm MC, Hampartzoumian T, and Hunt JE. IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor . Eur. J. Immunol. 2005. 35: 2376-2385.
2. Wang HW, McNeil HP, Husain A, Liu K, Tedla N, Thomas PS, Raftery M, King GC, Cai ZY, and Hunt JE. Delta (ä) tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity J Immunol 2002. 169: 5145-5152.
3. Hunt JE, Stevens RL, Austen KF, Zhang J, Xia Z, and Ghildyal N. Natural disruption of the mouse mast cell protease 7 (mMCP-7) gene in the C57BL/6 Mouse. J. Biol. Chem. 1996, 271(5):2851-2855.
4. Hunt JE, Friend DS, Gurish MF, Feyfant E, Sali A, Huang C, Ghildyal N, Stechshulte S, Austen KF and Stevens RL. Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells. J. Biol Chem. 1997, 272: 29158-29166.
5. Huang C, Li L, Krilis SA, Chanasyk K, Tang Y, Li Z, Hunt JE, and Stevens RL. Human tryptases alpha and beta are functionally distinct, due in part to a single amino acid difference in one of the surface loops that forms the substrate binding cleft. J. Biol Chem. 1999, 274: 19670-19676.
6. M Li, Liu K, Michalicek, Angus JA, Hunt JE, Graham RA, and A Husain. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 2004 114:112-120. | |
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