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Research InterestsDr Karen Gibson | | (Position Details) | | Phone 02 9385 3650 | | Email | | Qualifications MB BS, BMedSc, PhD UNSW |
| | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Physiology
Renal Disease
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| | | | Specific Research Keywords | |
| Fetal Development
Cardiovascular Development
Renal Disease
Hypertension
Renin-angiotensin system
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| | | | Research Interests | |
| There is considerable recent epidemiological evidence that the quality of life in utero influences the development of adult disease eg hypertension, cardiovascular disease and diabetes. Collaborative work with Prof E.R. Lumbers and Dr Amanda Boyce is concerned with renal development, cardiovascular development and the renin angiotensin system and possible programming for later disease.
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| | | | Teaching Interests | |
| Course organisation of PHPH3221 Endocrine, Reproductive and Developmental Physiology, which is offered to 3rd science students. Teaching involvement in a number of the physiology courses run by the Dept and in Phases 1 and 2 in the New Medical Program. Particular areas of expertise are renal physiology, fetal physiology, the ECG, and basic respiratory physiology. Facilitation in the New Medical Program (which commenced in 2004). Chair of ILP (Independent Learning Project) Committee. | |
| | | | Society Memberships & Professional Activities | |
| Australian Physiological and Pharmacological Society, Australian Society for Medical Research, Perinatal Society of Australia and New Zealand, American Physiological Society.
Review grants for NHMRC (Aust), NHF (Aust) and MRC (NZ).
Member of Grant Review Panel for NHMRC 2007, 2008
Review manuscripts for several peer review journals. | |
| | | | Funding Sources | |
| Kidney Health Australia
Heart Foundation
NHMRC | |
| | | | Key works/Publications | |
| Gibson KJ & Lumbers ER (1995). Extracellular volume and blood volume in chroncimally catheterized fetal sheep. Journal of Physiology 485, 835-844.
Gibson KJ & Lumbers ER (1999) Effects of bilateral nephrectomy and angiotensin II replacement on body fluids in fetal sheep. Clinical and Experimental Pharmacology and Physiology 26, 765-773.
Marsh AC, Gibson KJ, Wu J , Owens PC, Owens JA & Lumbers ER (2001). Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep. American Journal of Physiology: Regulatory Integrative and Comparative Physiology 281, R318-R326.
McMullen JR, Gibson KJ, Lumbers ER & Burrell JH (2002). 125I[Sar1Ile8]angiotensin II has a different affinity for AT1 and AT2 receptor subtypes in ovine tissues. Regulatory Peptides 105, 83-92.
Marsh AC, Lumbers ER & Gibson KJ (2002). Renal, cardiovascular and endocrine responses of fetal sheep at 0.8 of gestation to an infusion of amino acids. Journal of Physiology 540, 717-728.
O'Connell, A.E., Boyce, A.C., Lumbers, E.R. & Gibson, K.J. (2003). The effects of asphyxia on renal function in fetal sheep at midgestation. Journal of Physiology, 552, 933-943.
Gibson KJ, Thomson CL, Boyce AC, Karime BM & Lumbers ER. (2006). Effects of reduced renal mass on pregnancy, cardiovascular and renal function of the pregnant ewe. Am J Physiol Renal Physiol 290:F1153-F1162.
O’Connell, AE, Boyce, AC, Kumarasamy, V, Douglas-Denton, R, Bertram, JF and Gibson, KJ (2006). The long-term effects of a midgestational asphyxial episode in the ovine fetus. The Anatomical Record Part A 288A:1112-1120.
Gibson, K.J., Boyce, A.C., Karime, B.M. & Lumbers, E.R. (2007). Maternal renal insufficiency alters plasma composition and renal function in the fetal sheep. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 292: R1204-1211.
Boyce AC, Gibson KJ, Wintour EM, Koukoulas I, Gatford KL, Owens JA and Lumbers ER (2007). The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep. Canadian Journal of Physiology and Pharmacology 85, 597-605.
Boyce AC, Gibson KJ, Thomson CL, Lumbers ER (2008). Interactions between maternal subtotal nephrectomy and salt: effects on renal function and the composition of plasma in the late gestation sheep fetus. Experimental Physiology 93, 262-270.
Brandon AE, Boyce AC, Lumbers ER, Zimanyi MA, Bertram JF& Gibson KJ (2008). Glomerular hypertrophy in offspring of subtotally nephrectomised ewes. Anatomical Record 291, 318-324.
Gibson KJ, Boyce AC, Thomson CL, Chinchen S. & Lumbers ER (2008). Interactions between subtotal nephrectomy and salt; effects on blood pressure and renal function in pregnant and non-pregnant ewes. American Journal of Physiology - Regulatory, Integrative, Comparative 294, R1227-R1233.
Turner AJ, Brown RD, Carlstrom M, Gibson KJ & Persson AEG (2008). Mechanisms of neonatal increase in glomerular filtration rate. American Journal of Physiology - Regulatory, Integrative, Comparative 295, R916-921.
Brandon AE, Boyce AC, Lumbers ER & Gibson KJ (2009). Maternal renal dysfunction in sheep is associated with salt insensitivity in female offspring. Journal of Physiology 587, 261-270. | |
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