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Research InterestsDr Angela Finch | | (Position Details) | | Phone Please contact School/Unit | | | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Pharmacology
Molecular Structure & Drug Design
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| | | | Specific Research Keywords | |
| G-protein Coupled Receptors
Drug Discovery
Molecular Mechanisms
Pharmacology
Cell Biology
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| | | | Research Interests | |
| Research interests are G-Protein Coupled Receptor (GPCR), activation and regulation by drugs. The mechanisms of GPCR activation are being explored via: (i) examination of conserved residues within rhodopsin-like GPCRs, (ii) understanding the complexity of alpha1-adrenergic receptor (AR) signalling (iii) a drug discovery program, in collaboration with other members of the Department of Pharmacology, studying novel chemical frameworks as the basis of new alpha1-AR selective compounds for treatment of diseases such as hypertension and prostate cancer.
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| | | | Teaching Interests | |
| Broadly pharmacology with a specific focus on G-protein coupled receptors (including adrenergic receptors) and molecular pharmacology. | |
| | | | Society Memberships & Professional Activities | |
| ASCEPT | |
| | | | Key works/Publications | |
| 27. Antipatis C, Finch AM, Ashworth CJ. Effect of controlled alterations in maternal dietary retinol on foetal and neonatal retinol status and pregnancy outcome in pigs. Livestock Science 2008 118: 247-254
26. Riek RP, Finch AM, Begg GE, Graham RM. Wide turn diversity in protein transmembrane helices - implications for G-protein coupled receptor and other polytopic membrane protein structure and function. Mol Pharm Accepted January 17th, 2008
25. Laird AS, Finch AM, Waite PME, Carrive P. Peripheral changes above and below injury level lead to prolonged vascular responses following high spinal cord injury AJP: Heart and Circulatory Physiology Accepted 30th Nov 2007
24. McNeil CJ, Nwagwu MO, Finch AM, Page KP, Thain A, McArdle HJ, Ashworth CJ. Glucocorticoid exposure and tissue gene expression of 11β HSD-1, 11 β HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth. Reproduction 2007 133:653–661
23. Du XJ, Gao XM, Kiriazis H, Moore XL, Ming Z, Su Y, Finch AM, Hannan RA, Dart AM, Graham RM. Transgenic α1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res. 2006 71(4):735-43.
20. McNeil CJ, Finch AM, Page KR, Clarke SD, Ashworth CJ, McArdle HJ. The effect of fetal pig size and stage of gestation on tissue fatty acid metabolism and profile. Reproduction. 2005 129(6):757-63.
19. Du XJ, Fang L, Gao XM, Kiriazis H, Feng X, Hotchkin E, Finch AM, Chaulet H, Graham RM. Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction. J Mol Cell Cardiol. 2004 37(5):979-87.
18. Finch AM, Yang LG, Nwagwu MO, Page KR, McArdle HJ, Ashworth CJ. Placental transport of leucine in a porcine model of low birth weight. Reproduction. 2004 128(2):229-35.
17. McGinty SJ, Finch A, Griffith R, Graham RM, Bremner JB. Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective α1D-adrenergic receptor ligand. Bioorg Med Chem. 2004 12(21):5639-50. | |
| | | | Further Information | |
| http://medicalsciences.med.unsw.edu.au/SOMSWeb.nsf/page/The+Molecular+Pharmacology+of+G-Protein+Coupled+Receptors | |
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