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Research InterestsDr Gilles Guillemin | | (Position Details) | | Phone 02 8382 4916 | | Email | | Qualifications BSc (Hons), PhD University of Burgundy |
| | | School/Unit |
| St Vincent's Clinical School | |
| | Broad Research Areas | |
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Neuroscience
Immunology
Inflammation
Ageing
Neurodegenerative Diseases
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| | | | Specific Research Keywords | |
| Alzheimer's Disease
Neurochemistry
Dementia
Neurodegenerative Diseases
Amyotrophic lateral sclerosis
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| | | | Research Interests | |
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Involvement of tryptophan (an essential amino acid) and its derived molecules (kynurenines) in neurodegenerative diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, Prion diseases and Down syndrome. We are collaborating with neuroscientists in Australia, France, Spain, Italy, Germany, USA and Japan.
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| | | | Project Topics for current Honours Students |
| Honors projects:
- Expression of IDO in human fetal vs adult astrocytes
- Characterization of the kynurenine pathway in choroid plexus cells
- Characterization of the kynurenine pathway in human red blood cells
- Characterization of the kynurenine pathway in human platelets
- Characterization of the C Type lectin receptors in human brain cells
- effects of various interferons on IDO1, IDO2 and TDO expression
- Effects of quinolinic acid on inflammatory mediator production by human macrophages | |
| | | | Teaching Interests | |
| Laboratory based teaching : PhD and Honour students | |
| | | | Society Memberships & Professional Activities | |
| - Member of the executive committee of the International Neurotoxicity Society (NTS).
- Member of the executive committee of the International Society of Tryptophan research (ISTRY)
- Member of the International Society of Neuroscience (SFN).
- Member of the International Society of Neurovirology.
- Member of the Australian Society for Medical Research (ASMR).
- Member of the Australian Neuroscience Society (ANS) | |
| | | | Funding Sources | |
| The University of New South Wales
National Health & Medical Research Council (fellowship only)
St Vincent's Clinic Foundation
Australia Academy of Science
Alzheimer's Australia
Alzheimer's association USA
Perpetual Trust (Mason Foundation)
ALS Australia
Rebecca Cooper Foundation
Ramaciotti foundation
MS Research Australia | |
| | | | Other Postgraduate Research | |
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Methods:
- Cultures of human brain cells (neurons, astrocytes, microglia, oligodendrocytes)
- Molecular biology: nucleic acid extraction, PCR, RT-PCR, quantitative PCR.
- Flow cytometry, Immunocytochemistry and immunohistochemistry
- HPLC and mass spectrometry
- Western blot
Topics for Potential Students
1: The involvement of the kynurenine pathway in Parkinson disease
2: The kynurenine pathway in the pathology of AIDS dementia complex | |
| | | | Key works/Publications | |
| Last 2 years only:
IN PRESS :
2008
GG1. Impact of 27-hydroxycholesterol on amyloid-β peptide production and ATP-binding cassette transporter expression in primary human neurons. Woojin Scott Kim, Sharon L. Chan, Andrew F. Hill, Gilles J. Guillemin, and Brett Garner. J Alzheimer's Disease (IF 4.1)
GG2. Are the experimental models used to study neurodegeneration suitable to collect information to develop new therapy actions in neurodegenerative diseases? (REVIEW) Gilles j. Guillemin, Neurotoxicity Res. 2008
GG3. Neurodegeneration and Ageing in the HAART Era. Bruce J. Brew, SM Crowe, A Landay, Lucette A. Cysique, and Gilles J Guillemin. Journal of Neuroimmune Pharmacology.
PUBLISHED :
2009
GG4. Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors. Yiquan Chen, Vincent Meninger and Gilles J. Guillemin. Central Nervous System Agents in Medicinal Chemistry 2008.
2008
GG5. Promotion of Cellular NAD Anabolism: Therapeutic Potential for Oxidative Stress in Alzheimer’s Disease & Aging. Nady Braidy; Gilles J. Guillemin and Ross Grant. Neurotoxicity Research, 2008, VOL. 13(3,4). pp. 173-184 (IF 5.1, NC 0).
GG6. Serotonin decreases HIV-1 infection of human macrophages. Benjamin Maneglier, Gilles J Guillemin, Odile Spreux-Varoquaux, Benoit Malleret, Christine Rogez-Kreuz, Stephane Prost, Charles Advenier, Patrice Therond, Dominique Dormont and Pascal Clayette. Br J Pharmacol. 2008 May;154(1):174-82.
GG7. The involvement of astrocytes and kynurenine pathway in Alzheimer’s disease. (REVIEW). Ka Ka Ting, Bruce Brew and Gilles Guillemin. Neurotox Res 2008 12(4) 247-262.
2007
GG8. Characterization of the kynurenine pathway in human neurons. Gilles J. Guillemin, Karen Cullen, George Smythe, Vimal Kapoor, Edwin Lim, Brett Garner, Osamu Takikawa and Bruce J. Brew. The Journal of Neuroscience, November 21, 2007. 27(47): 12884-12892.
GG9. Characterization of the kynurenine pathway in primary human oligodendrocytes. Chai K. Lim, George Smythe, Roland Stocker, Bruce J. Brew, Gilles J. Guillemin. International Congress Series 1304 (2007) 213-217.
GG10. Chronic HIV infection leads to an Alzheimer’s disease like illness - Involvement of the kynurenine pathway. Gilles J. Guillemin and Bruce J. Brew. International Congress Series 1304 (2007) 324-334.
GG11. Mass spectrometric detection of quinolinic acid in microdissected Alzheimer disease plaques. Gilles J. Guillemin, Bruce J. Brew, Claire E. Noonan, Toby G. Knight and Karen M Cullen. International Congress Series 1304 (2007) 404-408.
GG12. Effect of Quinolinic acid on gene expression in human Astrocytes: Implications on Alzheimer’s disease. Ka Ka Ting, Bruce J. Brew and Gilles J. Guillemin. International Congress Series 1304 (2007) 384-388.
GG13. Inhibition par la sérotonine de l'infection par VIH-1 dans des macrophages en culture primaire: rôle du sous-type des récepteurs sérotoninergiques 5-HT1A. Benjamin Maneglier, Odile Spreux-Varoquaux; Gilles J Guillemin; Christine Rogez-kreuz; Dominique Dormont; Charles Advenier; Pascal Clayette. Pathol Biol (Paris). 2007 Dec; 55(10):495-503.
GG14. Primary Human Astrocytes Produce 24(S), 25-Epoxycholesterol with Implications for Brain Cholesterol Homeostasis. Jenny Wong, Carmel M. Quinn, Gilles J. Guillemin and Andrew J. Brown. J. Neurochem 2007 Dec: 103 (5):1764-73.
GG15. Novel functions for ABCG1 in the regulation of cholesterol efflux to apoE discs and neuronal generation of amyloid-beta peptide.Woojin S. Kim,, Aldwin Suryo, Alvin Kamili, Kerry-Anne Rye, Gilles J. Guillemin, Ingrid C. Gelissen, Wendy Jessup, Andrew F. Hill and Brett Garner. J Biol Chem 2007 Feb; (282 (5): 2851-61.
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