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Research InterestsProfessor Michael Grimm | | (Position Details) | | Phone 02 9113 2992 | | Email | | Qualifications MB BS Syd, PhD ANU, FRACP |
| | | School/Unit |
| St George Clinical School | | stgcs.med.unsw.edu.au
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| | Broad Research Areas | |
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Gastrointestinal Diseases
Immunology
Inflammation
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| | | | Specific Research Keywords | |
| Gastroenterology
Inflammatory Bowel Disease
Chemokines
Cytokines
Ethics
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| | | | Research Interests | |
| A number of research projects in the Department of Gastroenterology, St George Clinical School, and the Inflammatory Diseases Research Unit, School of Medical Sciences. The research areas include the following : cross-regulation of chemokines and chemokine receptors; immunopathogenesis of inflammatory bowel disease; novel therapeutic strategies in inflammatory bowel disease; mucosal immunity and lymphocyte trafficking; regulatory T lymphocytes and other mechanisms controlling gastrointestinal immunity; the role of the appendix in gut immunity and IBD
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| | | | ILP Research Interests (Will supervise ILP students) |
| Ethics Committees
Inflammation
Inflammatory Bowel Diseases
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| | | | Teaching Interests | |
| Interests in:
- transition to clinical teaching and learning
– case method teaching in integrated medical student education
- student mentoring
- learning for ethical practice | |
| | | | Society Memberships & Professional Activities | |
| Senior Presiding Member, UNSW Human Research Ethics Committee
Royal Australasian College of Physicians
Gastroenterological Society of Australia
– Councillor
– President-elect
American Gastroenterology Association
Australian Society for Immunology
Society for Mucosal Immunology | |
| | | | Funding Sources | |
| National Health and Medical Research Council | |
| | | | Key works/Publications | |
| Grimm MC, Ben-Baruch A, Taub DD, et al. (1998) Opiates trans-deactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. J Exp Med 188:317-325.
Ueda H, Howard OMZ, Grimm MC, Su S.-B, Gong W, Evans G, Ruscetti FW, Oppenheim JJ and Wang JM. (1998) HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes. J Clin Invest 102: 804-812
Biragyn A, Tani K, Grimm MC, Weeks S and Kwak LW. (1999) Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent anti-tumor immunity. Nature Biotechnol 17: 253-258
Davenport MP, Grimm MC, Lloyd AR. (2000) A homing selection hypothesis for T-cell trafficking. Immunol Today 21:315-317.
Grimm MC, Newman R, Cuan N, Connor SJ, Le Y, Wang JM, Oppenheim JJ and Lloyd AR. (2003) Cutting Edge: Vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors. J Immunol 171:4990-4994.
Connor SJ, Paraskevopoulos N, Newman R, Cuan N, Hampartzoumian T, Lloyd AR and Grimm MC (2004). CCR2-expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn’s disease. Gut 53: 1287-1294.
Newman R, Cuan N, Hampartzoumian T, Connor SJ, Lloyd AR, and Grimm MC (2005). Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis. Clin Exp Immunol 139: 411-420.
Jackson NE, Wang H-W, Tedla N, McNeil HP, GeczyCL, Collins A, Grimm MC, Hampartzoumian T and Hunt JE (2005). IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor. Eur J Immunol 35(8):2376-2385.
McNeil HP and Grimm MC (2005). Achieving equal standards in medical student education: is a national exit examination the answer?. Med J Aust 183: 166-168.
Ng WSW, Hampartzoumian T, Lloyd AR, Grimm MC. A murine model of appendicitis and the impact of inflammation on appendiceal lymphocyte constituents. Clin Exp Immunol 2007;150:169-178
Gibson KA, Boyle P, Black D, Cunningham M, Grimm MC and McNeil HP. Enhancing evaluation in a medical program. Academic Medicine 2008;83:787-793
Grimm MC, Ng WSW. Road most traveled – gut specific migration signals and leucocyte entry to the intestine. J Gastroenterol Hepatol 2008;23:1775-1776 | |
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