|
Research InterestsProfessor Minoti Apte | | (Position Details) | | Phone 02 9385 8273 | | Email | | Qualifications MB BS, MMedSci, PhD |
| | | School/Unit |
| South Western Sydney Clinical School | |
| | Broad Research Areas | |
|
Gastrointestinal Diseases
Cell Biology and Gene Regulation
Inflammation
| |
| | | | Specific Research Keywords | |
| Inflammation
Pancreatic cancer
Pancreatic stellate cells
Signalling and Transcription
Fibrogenesis
| |
| | | | Research Interests | |
|
Pancreatitis is a major complication of alcohol abuse. The pathogenesis of alcohol-induced pancreatic injury is a major interest. Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and pancreatic cancer. Mechanisms responsible for pancreatic fibrogenesis, in particular the role of pancreatic stellate cells in the fibrosis of chronic pancreatitis as well as pancreatic cancer is being studied. National and international collaborations have been set up to study the role of pancreatic stellate cells in the local and distant spread of pancreatic cancer.
| |
| | | | Project Topics for current Honours Students |
| Gene analysis of cancer-assoiciated and normal human pancreatic stellate cells | |
| | | | Society Memberships & Professional Activities | |
| Member, Gastroenterological Society of Australia
Member, Australian Society for Medical Research
Member, Australian Society for Experimental Pathology
Member, American Gastroenterological Association
Member, American Pancreatic Association
Founding Member and Past President, Australasian Pancreatic Club
Founding Member, Asian Oceanic Pancreatic Association
Member, Editorial Board, Pancreas
Member, Editorial Board, Pancreatology | |
| | | | Funding Sources | |
| National Health and Medical Research Council
Australian Research Counil
NSW Cancer Council | |
| | | | Other Postgraduate Research | |
|
The role of stromal cells and the epithelial-stromal reaction in the pathogenesis of pancreatic cancer is a topic currently under study. Pancreatic stellate cells have been found to be the predominant stromal cells in pancreatic cancer and the effect of their interaction with pancreatic tumour cells on the local and distant invasion of cancer is being investigated. | |
| | | | Key works/Publications | |
| 1) Apte MV, Haber PS, Applegate TN, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Periacinar stellate shaped cells in rat pancreas: identification, isolation and culture of stellate cells from rat pancreas. Gut, 43:128-133, 1998. [with cover illustration]
2) Apte MV, Haber PS, Darby SJ, Rodgers SC, Pirola RC, Korsten MA, McCaughan GW, Wilson JS. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut, 44:534-541, 1999.
3) Haber PS, Keogh GW, Apte MV, Moran CS, Stewart NL, Crawford DHG, Pirola RC, McCaughan GW, Ramm GA, Wilson JS. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. American Journal of Pathology, 155:1087-1095, 1999.
4) Apte MV, Phillips PA, Fahmy RA, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, Wilson JS. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118:780-794, 2000. [with cover illustration]
5) Mews P, Phillips P, Fahmy R, Pirola R, Korsten M, Wilson J, Apte M. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut, 50:535-541, 2002.
6) Phillips P, Wu M-J, Doherty E, Kumar RK, McCarroll J, Park S, Pirola R, Wilson J, Apte M. Cell migration : A novel aspect of pancreatic stellate cell biology. Gut 52:677-82, 2003.
7) Phillips PA, McCarroll JA, Park S, Wu M-J, Korsten MA, Pirola RC, Wilson JS, Apte MV. Pancreatic stellate cells secrete matrix metalloproteinases – implications for extracellular matrix turnover. Gut, 52:275-282, 2003.
8) McCarroll JA, Phillips PA, Kumar RK, Park S, Pirola RC, Wilson JS, Apte MV. (2004) Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase (PI3-kinase) pathway. Biochemical Pharmacology, 67:1215-1225.
9) Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm G, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola RC, Wilson JS. Role of epithelial-stromal interactions in the pathogenesis of pancreatic cancer. Pancreas, 29:179-187, 2004.
10) McCarroll J, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis.Gut, 55:79-89, 2006
11. A Vonlaufen, ZH Xu, B Daniel, S Joshi, C Toi, RK Kumar, R Pirola, J Wilson, MV Apte. Bacterial endotoxin – a trigger factor for alcoholic pancreatitis ? Evidence from a novel, physiologically relevant animal model. Gastroenterology, 133:1293-1303, 2007.
12. Apte M, Witt H, Keim V, Wilson J. Chronic Pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis and therapy. Gastroenterology 132:1557-1573, 2007.
13. A Vonlaufen, S Joshi, CF Qu, PS Phillips, CS Toi, ZH Xu, R Pirola, J Wilson, D.Goldstein, MV Apte. Pancreatic stellate cells induce pancreatic cancer growth : findings of a novel orthotopic model of pancreatic cancer. Cancer Research, in press, accepted February 2008.
14. Vonlaufen A, PhillipsPA, Xu Z, Goldstein D, Pirola RC, Wilson JS V. Apte M. Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance. Cancer Research, in press, accepted April 2008. | |
| | | | Attachments | |
|
pil.ttf | |
| | |
Profile last updated: 28/11/2008 Need to update your profile? Login to your profile with your Staff ID, prefixed by a lower case "s" or "z" (eg s1234567 or z1234567), and UniPass to update your profile. If you have any problems please send an email to .
|
|