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Research InterestsDr Gila Moalem-Taylor | | (Position Details) | | Phone 02 9385 2478 | | Email | | | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Pain
Neuroscience
Inflammation
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| | | | Specific Research Keywords | |
| Pain Research
Nerve Injury Pain
T Cells
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| | | | Research Interests | |
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Damage to the nervous system is often associated with chronic neuropathic pain symptoms including spontaneous pain, increased sensitivity to painful stimuli (hyperalgesia), and pain perceived in response to normally non-painful stimuli (allodynia). Such pain is extremely debilitating and difficult to treat. My current research focuses on the mechanisms underlying neuropathic pain, with particular emphasis on how immune cells and inflammatory mediators influence chronic pain following peripheral nerve injury or autoimmune inflammation in the nervous system.
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| | | | ILP Research Interests (Will supervise ILP students) |
| Pain
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| | | | Project Topics for current Honours Students |
| The role of the proinflammatory cytokine interleukin-17 in neuropathic pain | |
| | | | Society Memberships & Professional Activities | |
| Member of the Australian Neuroscience Society
Member of the International Association for the Study of Pain
Member of the International Society of Neuroimmunology | |
| | | | Funding Sources | |
| The Vice-Chancellor's Postdoctoral Research Fellowship, UNSW
UNSW Goldstar Award
NHMRC Project Grant | |
| | | | Other Postgraduate Research | |
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| | | | Key works/Publications | |
| Refereed journal articles and reviews
1. Hirschberg DL*, Moalem G*, He J, Mor F, Cohen IR & Schwartz M. Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma. (*Equal contributors)
J Neuroimmunol 89: 88-96 (1998).
2. Monsonego A, Mizrahi T, Eitan S, Moalem G, Bardos H, Adany R & Schwartz M. Factor XIIIa as a nerve-associated transglutaminase.
Faseb J 12: 1163-1171 (1998).
3. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR & Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy.
Nat Med 5: 49-55 (1999).
4. Ophir R, Moalem G, Pecht M, Shashoua M, Rashid G, Ben-Efraim S, Trainin N, Burstein Y & Keisari Y. THF-gamma 2-mediated reduction of pulmonary metastases and augmentation of immunocompetence in C57BL/6 mice bearing B16-melanoma.
J Immunother 22: 103-113 (1999).
5. Moalem G, Monsonego A, Shani Y, Cohen IR & Schwartz M. Differential T cell response in central and peripheral nerve injury: connection with immune privilege.
Faseb J 13: 1207-1217 (1999).
6. Schwartz M, Moalem G, Leibowitz-Amit R & Cohen IR. Innate and adaptive immune responses can be beneficial for CNS repair.
Trends Neurosci 22: 295-299 (1999). REVIEW.
7. Schwartz M, Cohen I, Lazarov-Spiegler O, Moalem G & Yoles E. The remedy may lie in ourselves: prospects for immune cell therapy in central nervous system protection and repair.
J Mol Med 77: 713-717 (1999). REVIEW.
8. Hauben E, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Akselrod S, Neeman M, Cohen IR & Schwartz M. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury.
Lancet 355: 286-287 (2000).
9. Moalem G, Yoles E, Leibowitz-Amit R, Muller-Gilor S, Mor F, Cohen IR & Schwartz M. Autoimmune T cells retard the loss of function in injured rat optic nerves.
J Neuroimmunol 106: 189-197 (2000).
10. Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Leibowitz-Amit R, Pevsner E, Akselrod S, Neeman M, Cohen IR & Schwartz M. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion.
J Neurosci 20: 6421-6430 (2000).
11. Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P, Cohen IR & Schwartz M. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity.
J Autoimmun 15: 331-345 (2000).
12. Schwartz M & Moalem G. Beneficial immune activity after CNS injury: prospects for vaccination.
J Neuroimmunol 113, 185-192 (2001). REVIEW.
13. Moalem G, Xu K & Yu L. T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats.
Neuroscience 129: 767-777 (2004).
14. Moalem G, Grafe P & Tracey DJ. Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat.
Neuroscience 134: 1399-1411 (2005).
15. Lang PM*, Moalem-Taylor G*, Tracey D, Bostock H & Grafe P. Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. (*Equal contributors)
J Neurophysiol 96: 2963-2971 (2006).
16. Moalem G & Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain.
Brain Res Brain Res Rev 51, 240-264 (2006). REVIEW.
17. Moalem-Taylor G, Allbutt HN, Iordanova MD & Tracey DJ. Pain hypersensitivity in rats with experimental autoimmune neuritis, an animal model of human inflammatory demyelinating neuropathy.
Brain Behav Immun 21: 699-710 (2007).
18. Moalem-Taylor G, Lang PM, Tracey DJ & Grafe P. Post-spike excitability indicates changes in membrane potential of isolated C-fibers.
Muscle Nerve 36:172-182 (2007).
19. Evans S, Moalem-Taylor G & Tracey DJ. Pain and endometriosis. REVIEW.
Pain 132 Suppl 1: S22-5 (2007).
20. Li M, Peake P, Charlesworth J, Tracey DJ & Moalem-Taylor G. Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats.
Eur J Neurosci 26: 3486–3500 (2007).
21. Smith F, Haskelberg H, Tracey DJ & Moalem-Taylor G. Role of Histamine H(3) and H(4) Receptors in Mechanical Hyperalgesia following Peripheral Nerve Injury.
Neuroimmunomodulation 14: 317-325 (2007) Epub 2008 Apr 10.
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